McMurray J J, Northridge D B, Abernethy V A, Lawson A A
Acute Medical Unit, Milesmark Hospital, Dunfermline, Fife, Scotland.
Q J Med. 1987 Oct;65(246):835-43.
All admissions for analgesic self-poisoning to a district poisons unit over a 15-year period have been reviewed. During this time overdose with analgesic drugs increased to represent almost half of all admissions for self-poisoning. The types of analgesics taken in overdose also changed significantly during the period of this review. Aspirin and Distalgesic poisoning declined in incidence and more cases of self-poisoning by paracetamol and non-steroidal anti-inflammatory agents were seen. The impact of these changes on the medical management and outcome of deliberate self-poisoning is analysed. The reasons behind the trends described in this paper are assessed and their implications for future prevention and treatment are discussed.
对某地区毒物中心15年间所有因镇痛药物自我中毒而入院的病例进行了回顾性研究。在此期间,因镇痛药物过量导致的入院人数增加,几乎占所有自我中毒入院人数的一半。在本回顾研究期间,过量服用的镇痛药物类型也发生了显著变化。阿司匹林和达而丰中毒的发生率下降,对乙酰氨基酚和非甾体抗炎药导致的自我中毒病例增多。分析了这些变化对蓄意自我中毒的医疗处理和结局的影响。评估了本文所述趋势背后的原因,并讨论了其对未来预防和治疗的意义。