Zubiaur Pablo, Mejía-Abril Gina, Navares-Gómez Marcos, Villapalos-García Gonzalo, Soria-Chacartegui Paula, Saiz-Rodríguez Miriam, Ochoa Dolores, Abad-Santos Francisco
Clinical Pharmacology Department, La Princesa University Hospital, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria La Princesa (IP), Universidad Autónoma de Madrid (UAM), 28029 Madrid, Spain.
UICEC Hospital Universitario de La Princesa, Plataforma SCReN (Spanish Clinical Research Network), Instituto de Investigación Sanitaria La Princesa (IP), 28006 Madrid, Spain.
J Clin Med. 2021 Aug 24;10(17):3772. doi: 10.3390/jcm10173772.
The implementation of clinical pharmacogenetics in daily practice is limited for various reasons. Today, however, it is a discipline in full expansion. Accordingly, in the recent times, several initiatives promoted its implementation, mainly in the United States but also in Europe. In this document, the genotyping results since the establishment of our Pharmacogenetics Unit in 2006 are described, as well as the historical implementation process that was carried out since then. Finally, this progress justified the constitution of La Princesa University Hospital Multidisciplinary Initiative for the Implementation of Pharmacogenetics (PriME-PGx), promoted by the Clinical Pharmacology Department of Hospital Universitario de La Princesa (Madrid, Spain). Here, we present the initiative along with the two first ongoing projects: the PROFILE project, which promotes modernization of pharmacogenetic reporting (i.e., from classic gene-drug pair reporting to complete pharmacogenetic reporting or the creation of pharmacogenetic profiles specific to the Hospital's departments) and the GENOTRIAL project, which promotes the communication of relevant pharmacogenetic findings to any healthy volunteer participating in any bioequivalence clinical trial at the Clinical Trials Unit of Hospital Universitario de La Princesa (UECHUP).
由于各种原因，临床药物遗传学在日常实践中的应用受到限制。然而，如今它是一门正在全面发展的学科。因此，近年来，多项举措推动了其应用，主要在美国，但欧洲也有。在本文档中，描述了自2006年我们的药物遗传学部门成立以来的基因分型结果，以及此后开展的历史应用过程。最后，这一进展为西班牙马德里公主大学医院临床药理学部推动的公主大学医院多学科药物遗传学实施倡议（PriME-PGx）的成立提供了依据。在此，我们介绍该倡议以及正在进行的前两个项目：PROFILE项目，该项目促进药物遗传学报告的现代化（即从经典的基因-药物对报告到完整的药物遗传学报告或创建医院各科室特定的药物遗传学图谱）和GENOTRIAL项目，该项目促进将相关药物遗传学研究结果传达给在公主大学医院临床试验单位（UECHUP）参与任何生物等效性临床试验的任何健康志愿者。
