Vrselja Amanda, Pillow J Jane, Black M Jane
Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, Australia.
School of Human Sciences, University of Western Australia, Perth, WA 6009, Australia.
J Clin Med. 2021 Aug 30;10(17):3896. doi: 10.3390/jcm10173896.
Preterm birth coincides with a key developmental window of cardiac growth and maturation, and thus has the potential to influence long-term cardiac function. Individuals born preterm have structural cardiac remodelling and altered cardiac growth and function by early adulthood. The evidence linking preterm birth and cardiovascular disease in later life is mounting. Advances in the perinatal care of preterm infants, such as glucocorticoid therapy, have improved survival rates, but at what cost? This review highlights the short-term and long-term impact of preterm birth on the structure and function of the heart and focuses on the impact of antenatal and postnatal glucocorticoid treatment on the immature preterm heart.
早产与心脏生长和成熟的关键发育窗口相吻合，因此有可能影响心脏的长期功能。早产个体在成年早期会出现心脏结构重塑以及心脏生长和功能改变。早产与晚年心血管疾病之间的联系证据越来越多。早产婴儿围产期护理的进展，如糖皮质激素治疗，提高了存活率，但代价是什么？这篇综述强调了早产对心脏结构和功能的短期和长期影响，并重点关注产前和产后糖皮质激素治疗对未成熟早产心脏的影响。
