Bensley Jonathan G, De Matteo Robert, Harding Richard, Black Mary J
Department of Anatomy and Developmental Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia.
Acta Obstet Gynecol Scand. 2016 Jun;95(6):652-63. doi: 10.1111/aogs.12880. Epub 2016 Mar 31.
Preterm birth occurs in approximately 10% of all births worldwide. It prematurely exposes the developing cardiovascular system to the hemodynamic transition that occurs at birth and to the subsequent functional demands of life ex utero. This review describes the current knowledge of the effects of preterm birth, and some of its common antecedents (chorioamnionitis, intra-uterine growth restriction, and maternal antenatal corticosteroid administration), on the structure of the myocardium.
A thorough literature search was conducted for articles relating to how preterm birth, and its antecedents, affect development of the heart. Given that sheep are an excellent model for the studies of cardiac development, this review has focused on experimental studies in sheep as well as clinical findings.
Our review of the literature demonstrates that individuals born preterm are at an increased risk of cardiovascular disease later in life, including increased mean arterial pressure, abnormally shaped and sub-optimally performing hearts and changes in the vasculature. The review highlights how antenatal corticosteroids, intra-uterine growth restriction, and exposure to chorioamnionitis also have the potential to impact cardiac growth in the preterm newborn.
Preterm birth and its common antecedents (antenatal corticosteroids, intra-uterine growth restriction, and chorioamnionitis) have the potential to adversely impact cardiac structure immediately following birth and in later life.
全球约10%的分娩为早产。早产使发育中的心血管系统过早暴露于出生时发生的血流动力学转变以及宫外生活随后的功能需求中。本综述描述了目前关于早产及其一些常见先兆（绒毛膜羊膜炎、宫内生长受限和母体产前使用皮质类固醇）对心肌结构影响的知识。
对有关早产及其先兆如何影响心脏发育的文章进行了全面的文献检索。鉴于绵羊是心脏发育研究的优秀模型，本综述重点关注了绵羊的实验研究以及临床发现。
我们对文献的综述表明，早产个体在生命后期患心血管疾病的风险增加，包括平均动脉压升高、心脏形状异常和功能欠佳以及血管系统变化。该综述强调了产前皮质类固醇、宫内生长受限和暴露于绒毛膜羊膜炎也有可能影响早产新生儿的心脏生长。
早产及其常见先兆（产前皮质类固醇、宫内生长受限和绒毛膜羊膜炎）有可能在出生后即刻及以后的生活中对心脏结构产生不利影响。
