Vlad-Sabin Ivan, Roxana Buzas, Adina-Flavia Cuțina Morgovan, Paul Ciubotaru, Melania Ardelean, Daniel Goje, Ilie Roșca Ciprian, Romulus Timar, Daniel Lighezan
Advanced Research Center for Cardiovascular Pathology and Haemostaseology, Department of Internal Medicine I-Medical Semiology I, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Nutrition and Metabolic Diseases, Department of Internal Medicine II-Diabetes, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
J Clin Med. 2021 Sep 6;10(17):4026. doi: 10.3390/jcm10174026.
As a byproduct of protein metabolism, serum uric acid is a controversial risk factor and is the focus of several recent studies in the field of cardiovascular disease. Whether serum uric acid is involved in the development of these pathologies alone or in conjunction with other factors is a matter of debate. The objective of this study is to assess the direct relationship between serum uric acid and the ejection fraction. A retrospective study of 303 patients with heart failure, classified according to the ESC guidelines, was conducted, and several parameters, along with the relationship between serum uric acid and ejection fraction, were characterized. A direct relationship between the level of serum uric acid and the ejection fraction was established ( 0.03); patients with higher uric acid had an increased risk of having a lower ejection fraction. : Serum uric acid, even when asymptomatic, is linked with the level of the ejection fraction of the left ventricle.
作为蛋白质代谢的副产物，血清尿酸是一个存在争议的风险因素，也是心血管疾病领域近期多项研究的焦点。血清尿酸是单独参与这些病理过程的发展，还是与其他因素共同作用，这是一个有争议的问题。本研究的目的是评估血清尿酸与射血分数之间的直接关系。对303例根据欧洲心脏病学会（ESC）指南分类的心力衰竭患者进行了回顾性研究，并对几个参数以及血清尿酸与射血分数之间的关系进行了表征。血清尿酸水平与射血分数之间建立了直接关系（P<0.03）；尿酸水平较高的患者射血分数较低的风险增加。结论：血清尿酸即使在无症状时也与左心室射血分数水平相关。
