Brupbacher Gavin, Zander-Schellenberg Thea, Straus Doris, Porschke Hildburg, Infanger Denis, Gerber Markus, von Känel Roland, Schmidt-Trucksäss Arno
Division of Sports and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Birsstrasse 320 B, 4052 Basel, Switzerland.
OBERWAID AG, Rorschacher Strasse 311, 9016 St. Gallen, Switzerland.
J Clin Med. 2021 Sep 6;10(17):4028. doi: 10.3390/jcm10174028.
Unipolar depression is associated with insomnia and autonomic arousal. The aim of this study was to quantify the effect of a single bout of aerobic exercise on nocturnal heart rate variability and pre-sleep arousal in patients with depression. This study was designed as a two-arm, parallel-group, randomized, outcome assessor-blinded, controlled, superiority trial. Patients with a primary diagnosis of unipolar depression aged 18-65 years were included. The intervention consisted of a single 30 min moderate-intensity aerobic exercise bout. The control group sat and read for 30 min. The primary outcome of interest was RMSSD during the sleep period assessed with polysomnography. Secondary outcomes were additional heart rate variability outcomes during the sleep and pre-sleep period as well as subjective pre-sleep arousal. A total of 92 patients were randomized to either the exercise ( = 46) or the control ( = 46) group. Intent-to-treat analysis ANCOVA of follow-up sleep period RMSSD, adjusted for baseline levels and minimization factors, did not detect a significant effect of the allocation (β = 0.12, = 0.94). There was no evidence for significant differences between both groups in any other heart rate variability measure nor in measures of cognitive or somatic pre-sleep arousal. As this is the first trial of its kind in this population, the findings need to be confirmed in further studies. Patients with depression should be encouraged to exercise regularly in order to profit from the known benefits on sleep and depressive symptoms, which are supported by extensive literature.
单相抑郁症与失眠和自主神经觉醒有关。本研究的目的是量化单次有氧运动对抑郁症患者夜间心率变异性和睡前觉醒的影响。本研究设计为双臂、平行组、随机、结果评估者盲法、对照、优效性试验。纳入年龄在18 - 65岁之间、初步诊断为单相抑郁症的患者。干预措施为单次30分钟的中等强度有氧运动。对照组坐下来阅读30分钟。主要关注的结果是通过多导睡眠图评估睡眠期间的RMSSD（相邻正常RR间期差值的均方根）。次要结果是睡眠期间和睡前期间的其他心率变异性结果以及主观睡前觉醒。共有92名患者被随机分为运动组（n = 46）或对照组（n = 46）。对随访睡眠期间的RMSSD进行意向性分析，采用协方差分析，并根据基线水平和最小化因素进行调整，未发现分组的显著影响（β = 0.12，P = 0.94）。两组在任何其他心率变异性测量指标以及认知或躯体睡前觉醒测量指标上均无显著差异的证据。由于这是该人群中的首例此类试验，研究结果需要在进一步研究中得到证实。应鼓励抑郁症患者定期锻炼，以便从睡眠和抑郁症状方面已知的益处中获益，大量文献对此提供了支持。
