Medical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
The Center for Sports Medicine and Health Sciences, Tsukuba University Hospital, Tsukuba 305-8576, Japan.
Int J Environ Res Public Health. 2021 Aug 25;18(17):8918. doi: 10.3390/ijerph18178918.
(1) Aim: Hepatic fibrosis is a prognostic factor for disease progression in non-alcoholic fatty liver disease (NAFLD). We aimed to determine the relationships between diet, physical activity, and the progression of liver fibrosis. (2) Methods: The 349 participants were categorized by their FibroScan-aspartate aminotransferase score, and they completed a questionnaire regarding their diet and physical activity. (3) Results: There were 233 patients in the negative-on-screening group, 78 in the gray zone group, and 38 in the positive-on-screening group. The frequencies of consumption of soybeans and soybean products and of light-colored vegetables were lower in the positive group; whereas the frequencies of consumption of snack food and fried sweets, jelly and pudding, fried food, and butter, lard, and beef tallow were higher. The odds ratios for the fibrosis progression in patients who consumed fried food ≥4 times/week was 2.21. The positive group also showed lower physical activity level (PAL) and exercise (Ex, metabolic equivalents for tasks (METs)/hour/week). The patients who undertook Ex at >7.5 had an odds ratio of 0.21 for the fibrosis progression. (4) Conclusion: High consumption of fried food and low Ex are risk factors for the fibrosis progression in NAFLD.
(1) 目的：肝纤维化是非酒精性脂肪性肝病（NAFLD）疾病进展的预后因素。我们旨在确定饮食、体力活动与肝纤维化进展之间的关系。(2) 方法：349 名参与者根据 FibroScan-天冬氨酸转氨酶评分进行分类，并完成了一份关于其饮食和体力活动的问卷。(3) 结果：在筛查阴性组中有 233 例患者，灰区组中有 78 例，筛查阳性组中有 38 例。阳性组中食用大豆及豆制品和浅色蔬菜的频率较低；而食用零食、油炸甜食、果冻布丁、油炸食品、黄油、猪油和牛肉脂肪的频率较高。每周食用油炸食品≥4 次的患者纤维化进展的比值比为 2.21。阳性组还表现出较低的体力活动水平（PAL）和运动（Ex，代谢当量任务/小时/周）。每周 Ex 超过 7.5 的患者纤维化进展的比值比为 0.21。(4) 结论：高油炸食品摄入和低 Ex 是 NAFLD 纤维化进展的危险因素。
