Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland.
Swiss TPH, University of Basel, Petersplatz 1, 4001 Basel, Switzerland.
Int J Environ Res Public Health. 2021 Aug 26;18(17):9021. doi: 10.3390/ijerph18179021.
Studies suggest that acute pesticide poisonings (APP) may be linked with long-term neurological effects. To examine long-term neurological and psychological distress symptoms associated with having experienced an APP, we conducted a cross-sectional study of 300 conventional and organic smallholder farmers from Zarcero County, Costa Rica, May-August 2016. We collected self-reported data on sociodemographic characteristics, occupational history, pesticide exposure, APPs, neurological and psychological distress symptoms (using the Brief Symptom Inventory (BSI)). Adjusted logistic regression models were fit. A total of 14% of the farmers (98% male) reported experiencing at least one APP during their lifetime. Self-reported APP was associated with neurological symptoms during the 12 months prior to interview (e.g., fainting (Odds Ratio: 7.48, 95% Confidence Interval: 1.83, 30.74), shaking hands (3.50; 1.60, 7.60), numbness/tingling in hands or feet (3.23; 1.66, 6.32), insomnia (2.53; 1.34, 4.79), accelerated heartrate (2.42; 1.03, 5.47), dizziness (2.38; 1.19, 4.72), increased irritability/anger (2.37; 1.23, 4.55), low energy (2.33; 1.23, 4.46), and difficulty concentrating (2.01; 1.05, 3.85)). Farmers who reported an APP in the ten years prior to interview experienced increased odds of abnormal BSI scores for hostility (4.51; 1.16, 17.70) and paranoid ideation (3.76; 0.99, 18.18). Having experienced an APP may be associated with long-term neurological and psychological distress symptoms.
研究表明，急性农药中毒（APP）可能与长期的神经影响有关。为了研究与经历 APP 相关的长期神经和心理困扰症状，我们于 2016 年 5 月至 8 月在哥斯达黎加扎塞科县对 300 名常规和有机小农进行了横断面研究。我们收集了社会人口特征、职业史、农药暴露、APP、神经和心理困扰症状（使用 Brief Symptom Inventory (BSI)）的自我报告数据。拟合了调整后的逻辑回归模型。共有 14%的农民（98%为男性）报告在其一生中至少经历过一次 APP。报告的 APP 与访谈前 12 个月的神经症状有关（例如，昏倒（优势比：7.48，95%置信区间：1.83，30.74）、握手（3.50；1.60，7.60）、手脚麻木/刺痛（3.23；1.66，6.32）、失眠（2.53；1.34，4.79）、心动过速（2.42；1.03，5.47）、头晕（2.38；1.19，4.72）、易怒/愤怒增加（2.37；1.23，4.55）、精力不足（2.33；1.23，4.46）和注意力集中困难（2.01；1.05，3.85））。在接受采访前十年报告 APP 的农民，其敌对情绪（4.51；1.16，17.70）和偏执观念（3.76；0.99，18.18）的 BSI 评分异常的几率增加。经历过 APP 可能与长期的神经和心理困扰症状有关。
