Department of Rehabilitation Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, Korea.
Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Korea.
Int J Environ Res Public Health. 2021 Aug 31;18(17):9165. doi: 10.3390/ijerph18179165.
Brown adipose tissue (BAT) plays an important role in thermogenic regulation, which contributes to alleviating diet-induced obesity through uncoupling protein 1 (UCP1) expression. While cold exposure and physical exercise are known to increase BAT development and UCP1 expression, the contribution of hyperbaric oxygen (HBO) therapy to BAT maturation remains largely unknown. Here, we show that HBO treatment sufficiently increases BAT volumes and thermogenic protein levels in Sprague-Dawley rats. Through F-FDG PET/CT analysis, we found that exposure to high-pressure oxygen (1.5-2.5 ATA) for 7 consecutive days increased radiolabeled glucose uptake and BAT development to an extent comparable to cold exposure. Consistent with BAT maturation, thermogenic protein levels, such as those of UCP1 and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), were largely increased by HBO treatment. Taken together, we suggest HBO therapy as a novel method of inducing BAT development, considering its therapeutic potential for the treatment of metabolic disorders.
棕色脂肪组织（BAT）在产热调节中发挥重要作用，通过解偶联蛋白 1（UCP1）的表达有助于缓解饮食诱导的肥胖。虽然已知寒冷暴露和体育锻炼会增加 BAT 的发育和 UCP1 的表达，但高压氧（HBO）治疗对 BAT 成熟的贡献在很大程度上仍不清楚。在这里，我们表明 HBO 治疗足以增加 Sprague-Dawley 大鼠的 BAT 体积和产热蛋白水平。通过 F-FDG PET/CT 分析，我们发现连续 7 天暴露于高压氧（1.5-2.5ATA）可增加放射性标记的葡萄糖摄取和 BAT 发育，程度可与寒冷暴露相媲美。与 BAT 成熟一致，产热蛋白水平，如 UCP1 和过氧化物酶体增殖物激活受体γ共激活因子 1α（PGC-1α），在很大程度上通过 HBO 治疗而增加。总之，考虑到其在治疗代谢紊乱方面的治疗潜力，我们建议将 HBO 治疗作为诱导 BAT 发育的新方法。
