Women's Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, UiT-The Arctic University of Norway, 9037 Tromsø, Norway.
Department of Obstetrics and Gynecology, University Hospital of North Norway, 9038 Tromsø, Norway.
Int J Environ Res Public Health. 2021 Sep 3;18(17):9330. doi: 10.3390/ijerph18179330.
Hormonal changes associated with pregnancy promote oral bacterial growth, which may affect salivary nitric oxide (NO) levels, oxidative stress (OS), and antioxidant capacity (AC). We hypothesized that caries-related bacterial load, NO level, and OS in the saliva change with advancing gestation. The aim of this study was to investigate longitudinal changes in salivary NO, OS, and AC during pregnancy and correlate them with () and () colonization at different stages of pregnancy. We assessed NO level by Griess method, OS by measuring malondialdehyde (MDA), AC by ABTS radicals and bacterial load by culturing and in the saliva of pregnant women ( = 96) and compared with non-pregnant women ( = 50) as well as between different stages of pregnancy. Compared with non-pregnant women, NO was 77% higher (4.73 ± 2.87 vs. 2.67 ± 1.55 µM; < 0.001), MDA was 13% higher (0.96 ± 0.27 vs. 0.85 ± 0.22 nM; = 0.0055), and AC was 34% lower (60.35 ± 14.33 vs. 80.82 ± 11.60%; < 0.001) in the late third trimester. NO increased with advancing gestation, but AC and OS did not change significantly during pregnancy. were more abundant in pregnant women compared with non-pregnant ( = 0.0012). Pregnancy appears to have an adverse impact on oral health emphasizing the importance optimal oral healthcare during pregnancy.
与妊娠相关的激素变化促进口腔细菌生长，这可能会影响唾液中的一氧化氮（NO）水平、氧化应激（OS）和抗氧化能力（AC）。我们假设与龋齿相关的细菌负荷、NO 水平和 OS 在妊娠期间会随着妊娠的进展而改变。本研究旨在探讨妊娠期间唾液中 NO、OS 和 AC 的纵向变化，并将其与妊娠不同阶段的 和 定植相关联。我们通过格里斯法评估 NO 水平，通过测量丙二醛（MDA）评估 OS，通过 ABTS 自由基评估 AC，并通过培养法评估 和 的细菌负荷，比较了孕妇（n = 96）和非孕妇（n = 50）的唾液中的这些指标，并比较了妊娠不同阶段之间的差异。与非孕妇相比，孕妇晚期的 NO 水平高 77%（4.73 ± 2.87 与 2.67 ± 1.55 µM； ＜0.001），MDA 水平高 13%（0.96 ± 0.27 与 0.85 ± 0.22 nM； = 0.0055），AC 水平低 34%（60.35 ± 14.33 与 80.82 ± 11.60%； ＜0.001）。NO 随着妊娠的进展而增加，但 AC 和 OS 在妊娠期间没有明显变化。与非孕妇相比，孕妇中 更为丰富（ = 0.0012）。妊娠似乎对口腔健康有不利影响，强调了妊娠期间进行最佳口腔保健的重要性。
