Michel P L, Aubert I, Boustani F, Acar J
Service de Cardiologie, Hôpital Tenon, Paris.
Ann Med Interne (Paris). 1987;138(8):610-4.
Seventy nine patients were operated for aortic regurgitation due to bacterial endocarditis confirmed anatomically at surgery between 1968 and 1984. They were classified into 3 groups according to the stage of endocarditis at the time of operation: progressive endocarditis (21 cases), recent endocarditis (39 cases) and late endocarditis (19 cases). The patients were adults (21 to 70 years) and predominantly male (82 p. 100). Previous valvular disease was found in 38 cases, bicuspid aortic valves were found in 21 cases. Most of the patients operated early (recent progressive endocarditis) had cardiac failure and the surgical indication was nearly always poor haemodynamic tolerance. In addition, this indication was also retained in late forms of the disease in patients usually panci-symptomatic in the presence of signs of increasing left ventricular dysfunction. The aortic lesion was the only pathology in 55 cases and was associated with periannular abscess in 8 cases, septal abscess in 5 cases including one with septal perforation, and mitral endocarditis in 12 cases. Seven patients died during surgery, in low output states in 6 cases (global mortality 8.9 p. 100). The 72 survivors were followed up for an average period of 5 years (4 to 168 months); three patients were lost to follow-up. The actuarial survival rate including the operative mortality was 77 p. 100 at 5 years and 64.6 p. 100 at 10 years. Valve dehiscence was common (52 p. 100); although the perivalvular leak was usually small, in 11 cases it was quite severe and 7 patients had to be reoperated. An excellent functional result was observed in 30 cases, especially in those patients operated early.
1968年至1984年间,79例因细菌性心内膜炎导致主动脉瓣关闭不全的患者接受了手术治疗,术中通过解剖确诊。根据手术时心内膜炎的阶段,他们被分为3组:进行性心内膜炎(21例)、近期心内膜炎(39例)和晚期心内膜炎(19例)。患者均为成年人(21至70岁),以男性为主(82%)。38例患者有既往瓣膜疾病,21例患者有二叶式主动脉瓣。大多数早期手术的患者(近期进行性心内膜炎)患有心力衰竭,手术指征几乎总是血流动力学耐受性差。此外,在疾病的晚期形式中,对于通常存在左心室功能障碍加重迹象且有全身症状的患者,该指征也适用。主动脉病变在55例中是唯一的病理改变,8例伴有瓣周脓肿,5例伴有间隔脓肿,其中1例伴有间隔穿孔,12例伴有二尖瓣心内膜炎。7例患者在手术期间死亡,6例处于低心排状态(总死亡率8.9%)。72名幸存者平均随访5年(4至168个月);3例患者失访。包括手术死亡率在内的5年精算生存率为77%,10年为64.6%。瓣膜裂开很常见(52%);尽管瓣周漏通常较小,但11例较为严重,7例患者不得不再次手术。30例患者观察到良好的功能结果,尤其是那些早期接受手术的患者。