Department of Food Technology and Nutrition, Lovely Professional University, Jalandhar 144411, Punjab, India.
Department of Vegetable Crops and Medicinal Plants, University of Life Sciences in Lublin, Doświadczalna Street, 20-280 Lublin, Poland.
Int J Mol Sci. 2021 Sep 4;22(17):9596. doi: 10.3390/ijms22179596.
In addition to the benefits, increasing the constant need for antibiotics has resulted in the development of antibiotic bacterial resistance over time. Antibiotic tolerance mainly evolves in these bacteria through efflux pumps and biofilms. Leading to its modern and profitable uses, emerging nanotechnology is a significant field of research that is considered as the most important scientific breakthrough in recent years. Metal nanoparticles as nanocarriers are currently attracting a lot of interest from scientists, because of their wide range of applications and higher compatibility with bioactive components. As a consequence of their ability to inhibit the growth of bacteria, nanoparticles have been shown to have significant antibacterial, antifungal, antiviral, and antiparasitic efficacy in the battle against antibiotic resistance in microorganisms. As a result, this study covers bacterial tolerance to antibiotics, the antibacterial properties of various metal nanoparticles, their mechanisms, and the use of various metal and metal oxide nanoparticles as novel antibiotic carriers for direct antibiotic delivery.
此外,随着抗生素的不断使用,细菌对抗生素的耐药性也逐渐增强。抗生素耐药性主要通过外排泵和生物膜在这些细菌中进化。新兴的纳米技术是一个重要的研究领域,被认为是近年来最重要的科学突破,它除了带来好处之外。作为纳米载体的金属纳米粒子目前引起了科学家们的极大兴趣,因为它们具有广泛的应用和更高的生物活性成分相容性。由于纳米粒子能够抑制细菌的生长,因此在对抗微生物的抗生素耐药性方面,它们具有显著的抗菌、抗真菌、抗病毒和抗寄生虫功效。因此,本研究涵盖了细菌对抗生素的耐药性、各种金属纳米粒子的抗菌特性、它们的作用机制以及各种金属和金属氧化物纳米粒子作为新型抗生素载体用于直接抗生素输送。