Kobayashi Nao, Oike Takahiro, Kubo Nobuteru, Miyasaka Yuhei, Mizukami Tatsuji, Sato Hiro, Adachi Akiko, Katoh Hiroyuki, Kawamura Hidemasa, Ohno Tatsuya
Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showamachi, Maebashi 371-8511, Japan.
Gunma University Heavy Ion Medical Center, 3-39-22 Showa-machi, Maebashi 371-8511, Japan.
Cancers (Basel). 2021 Sep 6;13(17):4481. doi: 10.3390/cancers13174481.
Colorectal cancer (CRC) screening is effective for detecting cancer in average-risk adults. For prostate cancer (PCa) patients considered for carbon ion radiotherapy (CIRT), pre-treatment CRC screening is performed empirically to avoid post-treatment colonoscopic manipulation. However, the outcomes of screening this population remain unclear. Here, we compared the outcomes of routine pre-CIRT CRC screening of 2412 PCa patients at average risk for CRC with data from two published datasets: the Japan National Cancer Registry (JNCR) and a series of 17 large-scale screening studies analyzing average-risk adults. The estimated prevalence rate was calculated using the pooled sensitivity elucidated by a previous meta-analysis. Consequently, 28 patients (1.16%) were diagnosed with CRC. CRC morbidity was significantly associated with high pre-treatment levels of prostate-specific antigen ( = 0.023). The screening positivity rate in this study cohort exceeded the annual incidence reported in the JNCR for most age brackets. Furthermore, the estimated prevalence rate in this study cohort (1.46%) exceeded that reported in all 17 large-scale studies, making the result an outlier ( = 0.005). These data indicate the possibility that the prevalence of CRC in PCa patients is greater than that in general average-risk adults, warranting further research in a prospective setting.
结直肠癌（CRC）筛查对于检测一般风险成年人中的癌症是有效的。对于考虑接受碳离子放疗（CIRT）的前列腺癌（PCa）患者，经验性地进行治疗前CRC筛查以避免治疗后结肠镜操作。然而，对这一人群进行筛查的结果仍不明确。在此，我们将2412例CRC一般风险的PCa患者的CIRT常规治疗前CRC筛查结果与两个已发表数据集的数据进行了比较：日本国家癌症登记处（JNCR）以及一系列分析一般风险成年人的17项大规模筛查研究。使用先前荟萃分析阐明的合并敏感性计算估计患病率。结果，28例患者（1.16%）被诊断为CRC。CRC发病率与治疗前高水平的前列腺特异性抗原显著相关（ = 0.023）。本研究队列中的筛查阳性率在大多数年龄组中超过了JNCR报告的年发病率。此外，本研究队列中的估计患病率（1.46%）超过了所有17项大规模研究报告的患病率，使该结果成为一个异常值（ = 0.005）。这些数据表明PCa患者中CRC的患病率可能高于一般一般风险成年人，值得在前瞻性研究中进一步探究。
