Eye Center, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Ophthalmology, People's Hospital of Kaihua, Kaihua, China.
BMC Ophthalmol. 2021 Sep 9;21(1):329. doi: 10.1186/s12886-021-02090-3.
To investigate the effects of small incision lenticule extraction (SMILE)-derived decellularized lenticules on intraocular pressure (IOP) and conjunctival scarring in a rabbit model of glaucoma filtration surgery.
Trabeculectomy was performed on both eyes of New Zealand rabbits. A decellularized lenticule was placed in the subconjunctival space in one eye of the rabbits (the decellularized lenticule group), and no adjunctive treatment was performed in the fellow eye (the control group). The filtering bleb features and IOP were evaluated 0, 3, 7, 14, 21, and 28 days after surgery, and histopathologic examination was performed 28 days after surgery.
Decellularized lenticules significantly increased bleb survival and decreased IOP postoperatively in the rabbit model with no adverse side effects. The histopathologic results showed a larger subconjunctival space and less subconjunctival fibrosis in the decellularized lenticule group.
Decellularized lenticules can prevent postoperative conjunctiva-sclera adhesion and fibrosis, and they may represent a novel antifibrotic agent for trabeculectomy.
为了研究小切口微透镜提取（SMILE）衍生的去细胞微透镜对青光眼滤过手术兔模型眼压（IOP）和结膜瘢痕形成的影响。
对新西兰兔双眼行小梁切除术。一只眼的结膜下间隙放置去细胞微透镜（去细胞微透镜组），对另一只眼不进行任何附加治疗（对照组）。术后 0、3、7、14、21 和 28 天评估滤过泡特征和 IOP，并在术后 28 天进行组织病理学检查。
去细胞微透镜在兔模型中显著增加了滤过泡的存活并降低了术后 IOP，且无不良反应。组织病理学结果显示，去细胞微透镜组结膜下间隙较大，结膜下纤维化程度较轻。
去细胞微透镜可防止术后结膜-巩膜粘连和纤维化，它们可能成为小梁切除术的一种新型抗纤维化药物。
