RNA 病毒感染对人体心血管系统的热力学效应。
Thermodynamic effect of RNA virus infection on the human cardiovascular system.
机构信息
Department of Mechanical Engineering, MCKV Institute of Engineering, Liluah, Howrah, 711204, India; Department of Mechanical Engineering, Jadavpur University, Kolkata, 700032, India.
Department of Mechanical Engineering, Jadavpur University, Kolkata, 700032, India.
出版信息
J Therm Biol. 2021 Aug;100:103039. doi: 10.1016/j.jtherbio.2021.103039. Epub 2021 Jun 29.
In this work, analysis of cardiovascular system under the influence of RNA virus infection has been performed from a thermodynamic perspective. An exergetic efficiency of the system has been defined for this purpose. Results show that except for asymptomatic case, the exergetic efficiency reduces as the viral load goes up. Dynamics of viral growth along with change in efficiency is examined under different parameters such as virus production rate, infectivity rate and cell death rate. Results show that the drop in the exergetic efficiency of cardiovascular system under viral infection can be up to about 20%. Under infection, the exergy requirement of the lungs increases significantly as the work rate required by lungs increase by up to 240%.
本工作从热力学角度分析了 RNA 病毒感染对心血管系统的影响，并为此定义了系统的火用效率。结果表明，除无症状病例外，随着病毒载量的增加，火用效率降低。在不同参数（如病毒产生率、感染率和细胞死亡率）下，研究了病毒生长的动力学及其效率变化。结果表明，病毒感染引起的心血管系统火用效率下降可达约 20%。在感染状态下，由于肺部所需的工作量增加了 240%，肺部的火用需求显著增加。
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