Institut Pasteur, Viral Populations and Pathogenesis Group and CNRS 3015, 75724 Paris Cedex 15, France.
Curr Opin Virol. 2011 Dec;1(6):643-8. doi: 10.1016/j.coviro.2011.09.012. Epub 2011 Oct 22.
RNA viruses are notorious for rapidly generating genetically diverse populations during a single replication cycle, and the implications of this mutant population, often referred to as quasispecies, can be vast. Previous studies have linked RNA virus genetic variability to changes in viral pathogenesis, the ability to adapt to a host during infection, and to the acquisition of mechanisms required to switch hosts entirely. However, these initial studies are just the beginning. With the development of next generation technologies, groups will be able to dig deeper into the sequence space that is generated during an RNA virus infection and more clearly understand the development, role, and consequences of viral genetic diversity.
RNA 病毒在单个复制周期内迅速产生遗传多样化群体，这一现象声名狼藉，而这种突变群体，通常被称为准种，其影响可能是深远的。先前的研究将 RNA 病毒遗传变异性与病毒发病机制的变化、在感染期间适应宿主的能力以及获得完全切换宿主所需的机制联系起来。然而，这些初步研究只是一个开始。随着下一代技术的发展，研究小组将能够更深入地挖掘 RNA 病毒感染过程中产生的序列空间，并更清楚地了解病毒遗传多样性的发展、作用和后果。
