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[摩洛哥医院工作人员中乙肝病毒表面抗原系统标志物的流行情况:乙肝感染风险评估]

[Prevalence of markers of the HBs system of hepatitis B among hospital personnel in Morocco: evaluation of the risk of hepatitis B infection].

作者信息

Rioche M

机构信息

Service de Virologie-Immunologie, Institut Pasteur du Maroc, Casablanca.

出版信息

Bull Soc Pathol Exot Filiales. 1987;80(5):745-50.

PMID:3450438
Abstract

The prevalences of HBs Ag and HBs Ab were investigated among 221 hospital or laboratory staffs in Casablanca (Morocco) to estimate the importance of risks of infection by HBV at which they were exposed with regard to a control group including 195 blood givers from the city. Staff originated from following departments: infectious diseases, emergency, blood center, haemodialysis and a laboratory associated to this one. HBs Ag has been investigated by inhibition of haemagglutination and HBs Ab by passive haemagglutination. X2 test, with Yates correction if need, was used as statistical. method. HBs Ag and Ab prevalences, higher among hospital staff than in controls (p less than 0.05), showed an increased risk of HBV infection in the formers. Among staff, whatever one's occupation may be, HBs Ab prevalence did not shown appreciable changes. In contrast, the HBs Ag one varied significantly from one department to the other, depending on factors such as hygiene and asepsis, reducing the risk, and contagiousness of some hospitalized patients or more or less frequent exposures to infectious blood, increasing the risk. The influence of these factors was illustrated and discussed by comparison of HBs Ag prevalence with frequency or importance of infectious exposures among staff from each studied department. As reported in various countries, in Morocco hospital and laboratory staff is exposed to a high risk of infection by HBV and the interest to vaccine such persons against hepatitis B is underlined.

摘要

在卡萨布兰卡(摩洛哥)的221名医院或实验室工作人员中调查了乙肝表面抗原(HBs Ag)和乙肝表面抗体(HBs Ab)的流行情况,以评估他们相对于包括该市195名献血者在内的对照组而言,接触乙肝病毒(HBV)感染风险的重要性。工作人员来自以下科室:传染病科、急诊科、血液中心、血液透析科以及与之相关的一个实验室。采用血凝抑制法检测HBs Ag,被动血凝法检测HBs Ab。统计学方法采用X²检验,必要时进行耶茨校正。医院工作人员中HBs Ag和抗体的流行率高于对照组(p<0.05),表明前者感染HBV的风险增加。在工作人员中,无论其职业如何,HBs Ab的流行率没有明显变化。相比之下,HBs Ag的流行率在不同科室之间有显著差异,这取决于卫生和无菌操作等因素(这些因素降低了风险)以及一些住院患者的传染性或或多或少频繁接触感染性血液(这些因素增加了风险)。通过比较每个研究科室工作人员中HBs Ag的流行率与感染性暴露的频率或重要性,阐述并讨论了这些因素的影响。正如各国所报道的那样,在摩洛哥,医院和实验室工作人员面临着感染HBV的高风险,强调了为这些人接种乙肝疫苗的重要性。

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