• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗坏血酸抑制肝癌生长和转移，且与干性基因调控无关。

Ascorbic Acid Inhibits Liver Cancer Growth and Metastasis and , Independent of Stemness Gene Regulation.

作者信息

Wan Jingjing, Zhou Juan, Fu Lu, Li Yubin, Zeng Huawu, Xu Xike, Lv Chao, Jin Huizi

机构信息

School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.

School of Pharmacy, Naval Medical University, Shanghai, China.

出版信息

Front Pharmacol. 2021 Aug 24;12:726015. doi: 10.3389/fphar.2021.726015. eCollection 2021.

DOI:10.3389/fphar.2021.726015
PMID:34504430
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8422961/
Abstract

Experimental and clinical evidence has indicated that the natural product ascorbic acid (AA) is effective in preventing and treating various types of cancers. However, the effect of AA on liver cancer metastasis has not yet been reported. Cancer stem cells (CSCs) play pivotal roles in cancer metastasis. Here, we demonstrated that AA selectively inhibited the viability of both liver cancer cells and CSCs, reduced the formation of cancer cell colonies and CSC spheres, and inhibited tumor growth . Additionally, AA prevented liver cancer metastasis in a xenotransplantation model without suppressing stemness gene expression in liver CSCs. Further study indicated that AA increased the concentration of HO and induced apoptosis in liver CSCs. Catalase attenuated the inhibitory effects of AA on liver CSC viability. In conclusion, AA inhibited the viability of liver CSCs and the growth and metastasis of liver cancer cells and by increasing the production of HO and inducing apoptosis. Our findings provide evidence that AA exerts its anti-liver cancer efficacy and , in a manner that is independent of stemness gene regulation.

摘要

实验和临床证据表明，天然产物抗坏血酸（AA）在预防和治疗各类癌症方面具有疗效。然而，AA对肝癌转移的影响尚未见报道。癌症干细胞（CSCs）在癌症转移中起关键作用。在此，我们证明AA能选择性抑制肝癌细胞和CSCs的活力，减少癌细胞集落和CSC球状体的形成，并抑制肿瘤生长。此外，AA在异种移植模型中可预防肝癌转移，且不抑制肝CSCs中的干性基因表达。进一步研究表明，AA可增加HO的浓度并诱导肝CSCs凋亡。过氧化氢酶可减弱AA对肝CSC活力的抑制作用。总之，AA通过增加HO的产生并诱导凋亡，抑制了肝CSCs的活力以及肝癌细胞的生长和转移。我们的研究结果提供了证据，表明AA以一种独立于干性基因调控的方式发挥其抗肝癌功效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8422961/131775041381/fphar-12-726015-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8422961/65509362f34c/fphar-12-726015-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8422961/b2c63d2cada7/fphar-12-726015-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8422961/b3a951e96740/fphar-12-726015-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8422961/b792273ad169/fphar-12-726015-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8422961/1ea64cdf11af/fphar-12-726015-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8422961/25d223d9174a/fphar-12-726015-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8422961/131775041381/fphar-12-726015-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8422961/65509362f34c/fphar-12-726015-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8422961/b2c63d2cada7/fphar-12-726015-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8422961/b3a951e96740/fphar-12-726015-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8422961/b792273ad169/fphar-12-726015-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8422961/1ea64cdf11af/fphar-12-726015-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8422961/25d223d9174a/fphar-12-726015-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ef/8422961/131775041381/fphar-12-726015-g007.jpg

相似文献

1
Ascorbic Acid Inhibits Liver Cancer Growth and Metastasis and , Independent of Stemness Gene Regulation.抗坏血酸抑制肝癌生长和转移，且与干性基因调控无关。
Front Pharmacol. 2021 Aug 24;12:726015. doi: 10.3389/fphar.2021.726015. eCollection 2021.
2
Zoledronic acid inhibits the growth of cancer stem cell derived from cervical cancer cell by attenuating their stemness phenotype and inducing apoptosis and cell cycle arrest through the Erk1/2 and Akt pathways.唑来膦酸通过 Erk1/2 和 Akt 通路抑制宫颈癌肿瘤干细胞的干性表型，并诱导其凋亡和细胞周期停滞，从而抑制其生长。
J Exp Clin Cancer Res. 2019 Feb 21;38(1):93. doi: 10.1186/s13046-019-1109-z.
3
Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells.谷胱甘肽代谢对于胰腺癌干细胞的自我更新和化疗耐药性至关重要。
World J Stem Cells. 2020 Nov 26;12(11):1410-1428. doi: 10.4252/wjsc.v12.i11.1410.
4
The natural agent 4-vinylphenol targets metastasis and stemness features in breast cancer stem-like cells.天然物质 4-乙烯基苯酚靶向乳腺癌干细胞的转移和干性特征。
Cancer Chemother Pharmacol. 2018 Aug;82(2):185-197. doi: 10.1007/s00280-018-3601-0. Epub 2018 May 18.
5
Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway.靶向谷氨酰胺酶 1 通过增加活性氧物种和抑制 Wnt/β-连环蛋白通路来减弱肝癌的干性特征。
EBioMedicine. 2019 Jan;39:239-254. doi: 10.1016/j.ebiom.2018.11.063. Epub 2018 Dec 13.
6
Knocking down LSD1 inhibits the stemness features of colorectal cancer stem cells.敲低 LSD1 抑制结直肠肿瘤干细胞的干性特征。
Braz J Med Biol Res. 2020 Jun 3;53(7):e9230. doi: 10.1590/1414-431X20209230. eCollection 2020.
7
Esculentoside A suppresses breast cancer stem cell growth through stemness attenuation and apoptosis induction by blocking IL-6/STAT3 signaling pathway.Esculentoside A 通过阻断 IL-6/STAT3 信号通路抑制乳腺癌干细胞的生长，减弱干性并诱导细胞凋亡。
Phytother Res. 2018 Nov;32(11):2299-2311. doi: 10.1002/ptr.6172. Epub 2018 Aug 6.
8
Suppression of miR-204 enables oral squamous cell carcinomas to promote cancer stemness, EMT traits, and lymph node metastasis.miR-204的抑制使口腔鳞状细胞癌能够促进癌症干性、上皮-间质转化特征和淋巴结转移。
Oncotarget. 2016 Apr 12;7(15):20180-92. doi: 10.18632/oncotarget.7745.
9
ZnAs@SiO nanoparticles as a potential anti-tumor drug for targeting stemness and epithelial-mesenchymal transition in hepatocellular carcinoma via SHP-1/JAK2/STAT3 signaling.ZnAs@SiO 纳米颗粒作为一种潜在的抗肿瘤药物，通过 SHP-1/JAK2/STAT3 信号通路靶向肝癌中的干性和上皮-间充质转化。
Theranostics. 2019 Jun 9;9(15):4391-4408. doi: 10.7150/thno.32462. eCollection 2019.
10
2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells.从虎杖中提取的新型小分子 STAT3 信号抑制剂 2-乙氧基紫檀烷酮，能够抑制肝癌细胞和 HCC 肿瘤干细胞的生长并诱导其凋亡。
BMC Complement Altern Med. 2019 Feb 1;19(1):38. doi: 10.1186/s12906-019-2440-9.

引用本文的文献

1
Exploring the therapeutic potential of natural compounds against hepatocellular carcinoma (HCC): a computational approach.探索天然化合物对肝细胞癌（HCC）的治疗潜力：一种计算方法。
EXCLI J. 2024 Nov 26;23:1440-1458. doi: 10.17179/excli2024-7970. eCollection 2024.
2
Acerola () Anti-Inflammatory Activity-A Review.樱桃（）的抗炎活性综述。
Int J Mol Sci. 2024 Feb 8;25(4):2089. doi: 10.3390/ijms25042089.
3
Role of Vitamin C in Targeting Cancer Stem Cells and Cellular Plasticity.维生素C在靶向癌症干细胞和细胞可塑性方面的作用。

本文引用的文献

1
Deficiency in Embryonic Stem Cell Marker Reduced Expression 1 Activates Mitogen-Activated Protein Kinase Kinase 6-Dependent p38 Mitogen-Activated Protein Kinase Signaling to Drive Hepatocarcinogenesis.胚胎干细胞标志物缺失降低表达 1 激活丝裂原活化蛋白激酶激酶 6 依赖性 p38 丝裂原活化蛋白激酶信号通路，驱动肝癌发生。
Hepatology. 2020 Jul;72(1):183-197. doi: 10.1002/hep.31020. Epub 2020 Apr 8.
2
Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2.维生素C通过SVCT-2优先杀死肝细胞癌中的癌症干细胞。
NPJ Precis Oncol. 2018 Jan 8;2(1):1. doi: 10.1038/s41698-017-0044-8. eCollection 2018.
3
Cancers (Basel). 2023 Nov 30;15(23):5657. doi: 10.3390/cancers15235657.
4
Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment.将维生素C重新用于癌症治疗：聚焦于靶向肿瘤微环境
Cancers (Basel). 2022 May 25;14(11):2608. doi: 10.3390/cancers14112608.
Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells.
肠道微生物群介导的胆汁酸代谢通过 NKT 细胞调节肝癌。
Science. 2018 May 25;360(6391). doi: 10.1126/science.aan5931.
4
Inhibition of cancer stem cell like cells by a synthetic retinoid.合成维甲酸抑制癌症干细胞样细胞。
Nat Commun. 2018 Apr 11;9(1):1406. doi: 10.1038/s41467-018-03877-7.
5
Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer.氧化还原悖论：一种治疗抵抗性癌症的新方法。
Antioxid Redox Signal. 2018 Nov 1;29(13):1237-1272. doi: 10.1089/ars.2017.7485. Epub 2018 Feb 21.
6
MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists.miR-31 通过抑制 Wnt 信号通路拮抗剂促进乳腺干细胞扩增和乳腺癌发生。
Nat Commun. 2017 Oct 19;8(1):1036. doi: 10.1038/s41467-017-01059-5.
7
Expression of sex-determining region Y-box protein 2 in breast cancer and its clinical significance.性别决定区Y盒蛋白2在乳腺癌中的表达及其临床意义。
Saudi Med J. 2017 Jul;38(7):685-690. doi: 10.15537/smj.2017.7.19372.
8
Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways.鸦胆子素D通过靶向β-连环蛋白/锯齿蛋白1信号通路抑制肝癌生长。
Cancer Lett. 2017 Sep 10;403:195-205. doi: 10.1016/j.canlet.2017.06.014. Epub 2017 Jun 20.
9
O and HO-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.氧和羟基介导的铁代谢紊乱导致非小细胞肺癌和胶质母细胞瘤癌细胞对药理剂量抗坏血酸的敏感性差异。
Cancer Cell. 2017 Apr 10;31(4):487-500.e8. doi: 10.1016/j.ccell.2017.02.018. Epub 2017 Mar 30.
10
A distinct role for Lgr5 stem cells in primary and metastatic colon cancer.Lgr5 干细胞在原发性和转移性结肠癌中的独特作用。
Nature. 2017 Mar 29;543(7647):676-680. doi: 10.1038/nature21713.