Li Wen-Ning, Zhang Shi-Jiao, Feng Jia-Qing, Jin Wei-Lin
The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, Lanzhou 730000, China.
Cancers (Basel). 2022 May 25;14(11):2608. doi: 10.3390/cancers14112608.
Based on the enhanced knowledge on the tumor microenvironment (TME), a more comprehensive treatment landscape for targeting the TME has emerged. This microenvironment provides multiple therapeutic targets due to its diverse characteristics, leading to numerous TME-targeted strategies. With multifaced activities targeting tumors and the TME, vitamin C is renown as a promising candidate for combination therapy. In this review, we present new advances in how vitamin C reshapes the TME in the immune, hypoxic, metabolic, acidic, neurological, mechanical, and microbial dimensions. These findings will open new possibilities for multiple therapeutic avenues in the fight against cancer. We also review the available preclinical and clinical evidence of vitamin C combined with established therapies, highlighting vitamin C as an adjuvant that can be exploited for novel therapeutics. Finally, we discuss unresolved questions and directions that merit further investigation.
基于对肿瘤微环境（TME）的深入了解，针对TME的更全面治疗格局已经出现。由于其多样的特性，这种微环境提供了多个治疗靶点，从而产生了众多针对TME的策略。维生素C因其针对肿瘤和TME的多方面作用，被誉为联合治疗的有前景候选药物。在本综述中，我们阐述了维生素C如何在免疫、缺氧、代谢、酸性、神经、机械和微生物等维度重塑TME的新进展。这些发现将为抗癌的多种治疗途径开辟新的可能性。我们还回顾了维生素C与现有疗法联合应用的临床前和临床证据，强调维生素C作为一种佐剂可用于新型治疗。最后，我们讨论了有待解决的问题和值得进一步研究的方向。
