Flor-Henry P
Alberta Hospital, Edmonton, Canada.
Encephale. 1987 Nov-Dec;13(6):329-33.
There are correlations between schizophrenia and the limbic seizure system on the one hand and the manic-depressive or bipolar syndromes and the generalized seizure system on the other hand, which are theoretically related to the different (although overlapping) neural substrates underlying the two major syndromes of psychosis. Evidence is reviewed that indicates that in ECT-responsive depression (with both bilateral and unilateral nondominant ECT) the modus operandi hinges on right-hemispheric neural events. At the same time the relevance of the complex interactions existing between limbic and generalized seizures, REM suppression, right limbic epilepsy and REM activation is discussed as well as the role of carbamazepine in these interactions.
一方面，精神分裂症与边缘性癫痫发作系统之间存在关联，另一方面，躁狂抑郁或双相情感障碍综合征与全身性癫痫发作系统之间存在关联，从理论上讲，这与两种主要精神病综合征背后不同（尽管有重叠）的神经基质有关。本文回顾了相关证据，这些证据表明，在对ECT有反应的抑郁症（包括双侧和单侧非优势侧ECT）中，其作用方式取决于右半球神经活动。同时，还讨论了边缘性癫痫发作与全身性癫痫发作、快速眼动睡眠抑制、右侧边缘性癫痫和快速眼动睡眠激活之间复杂相互作用的相关性，以及卡马西平在这些相互作用中的作用。
