Flor-Henry P
Ann N Y Acad Sci. 1986;462:389-97. doi: 10.1111/j.1749-6632.1986.tb51273.x.
The neurophysiological systems subtending generalized seizures (activated by ECT) and temporal-limbic seizures are described as well as the interactions existing between the two seizure systems. There are correlations between schizophrenia and the limbic seizure system on the one hand and the manic-depressive or bipolar syndromes and the generalized seizure system on the other which are theoretically related to the different (although overlapping) neural substrates underlying the two major syndromes of psychosis. Evidence is reviewed that indicates that in ECT-responsive depression (with both bilateral and unilateral nondominant ECT) the modus operandi hinges on right-hemispheric neural events. Neurophysiological, neurological, and acoustic threshold evidence is discussed: all of which emphasizes the importance of the nondominant hemisphere in the genesis of endogenous depressions and in their treatment with convulsive therapies. In addition, studies showing that psychotropic agents with specific antidepressant effects produce asymmetric activation of the right hemisphere (EEG) are related to the above issues.
本文描述了全身性癫痫发作（由ECT激活）和颞叶-边缘系统癫痫发作所涉及的神经生理系统，以及两个癫痫发作系统之间存在的相互作用。一方面，精神分裂症与边缘系统癫痫发作系统之间存在关联，另一方面，躁狂抑郁或双相综合征与全身性癫痫发作系统之间也存在关联，从理论上讲，这与两种主要精神病综合征背后不同（尽管有重叠）的神经基质有关。有证据表明，在ECT反应性抑郁症（包括双侧和单侧非优势侧ECT）中，其作用方式取决于右半球神经事件。文中讨论了神经生理学、神经学和听觉阈值方面的证据：所有这些证据都强调了非优势半球在内源性抑郁症的发生及其惊厥治疗中的重要性。此外，显示具有特定抗抑郁作用的精神药物会引起右半球不对称激活（脑电图）的研究也与上述问题相关。
