Eudowood Division of Pediatric Respiratory Sciences, School of Medicine, Johns Hopkins University, Baltimore, Md.
Division of Pediatric Allergy and Immunology, Children's National Medical Center, Washington, DC.
J Allergy Clin Immunol Pract. 2021 Dec;9(12):4402-4409.e2. doi: 10.1016/j.jaip.2021.08.031. Epub 2021 Sep 8.
Whether concomitant home exposures modify the effectiveness of mouse allergen reduction among mouse-sensitized children with asthma is unknown.
To determine whether a lower baseline home mouse allergen level, lower particulate matter 10 μ or less (PM), and the absence of sensitization and exposure to other indoor allergens are associated with greater improvements in asthma associated with mouse allergen reduction.
A secondary analysis of a randomized clinical trial of a home mouse allergen intervention was performed to examine the effect of 3 indoor factors on the relationship between mouse allergen reduction and a range of asthma outcomes.
Participants (N = 297) were predominantly minority (78% African American, 22% Hispanic) and publicly insured (88%). Higher baseline mouse allergen levels were associated with a greater response to mouse allergen reduction for several symptom and exacerbation outcomes. Lower indoor PM levels were associated with a greater response to mouse allergen reduction for several symptom outcomes, but not exacerbation outcomes. Overall, sensitization and exposure to other indoor allergens did not appear to modify the effect of mouse allergen reduction.
In this population of predominantly low-income children with persistent asthma and mouse sensitization, mouse allergen reduction was associated with improvements in asthma, especially among those with high baseline mouse allergen exposure. Lower indoor PM was associated with greater improvements in asthma symptoms.
尚不清楚家中同时存在的过敏原暴露是否会影响哮喘合并屋尘螨致敏儿童的屋尘螨减敏治疗效果。
旨在明确较低的基线室内屋尘螨浓度、较低的细颗粒物（PM10）浓度、无致敏和暴露于其他室内过敏原与屋尘螨减敏治疗对哮喘相关改善的效果是否更强之间的相关性。
对屋尘螨变应原家庭干预的一项随机临床试验进行二次分析，以评估 3 个室内因素对屋尘螨减少与一系列哮喘结局之间关系的影响。
参与者（N=297）主要为少数族裔（78%为非裔美国人，22%为西班牙裔）和公共保险人群（88%）。较高的基线屋尘螨水平与对屋尘螨减少的多种症状和加重结局的反应性更强相关。较低的室内 PM10 水平与对屋尘螨减少的多种症状结局的反应性更强相关，但与加重结局无关。总体而言，致敏和暴露于其他室内过敏原似乎并未改变屋尘螨减少的效果。
在这群持续存在哮喘且屋尘螨致敏的以低收入为主的儿童中，屋尘螨减少与哮喘的改善相关，尤其是在基线屋尘螨暴露较高的患者中。较低的室内 PM10 与哮喘症状的改善程度更强相关。
