Institute for Maternal and Child Health IRCCS Burlo Garofolo.
Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste.
J Pediatr Gastroenterol Nutr. 2022 Jan 1;74(1):91-95. doi: 10.1097/MPG.0000000000003295.
To investigate the compliance to the gluten-free diet in a cohort of adult celiac patients 20 years after the diagnosis, received in childhood through a mass screening.
This is an observational historic cohort follow-up study. It was carried out at the Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy. Two matched cohorts of adult celiac patients, diagnosed in childhood through a mass screening or for symptoms were enrolled. Adherence to the gluten free-diet and development of autoimmune diseases were investigated through a questionnaire administrated in the course of a phone interview.The primary study outcome was the adherence to the gluten-free diet, measured through the Biagi questionnaire, in the two cohorts of celiac patients.
We contacted 25 patients (mean age 28 years, 19 females) diagnosed with screening and 34 patients (mean age 25 years, 26 females) diagnosed in the same period for symptoms. After 20 years, in the cohort diagnosed with screening and in the cohort diagnosed for symptoms the adherence to the gluten-free diet was optimal in 14 (56%) and 26 (81%), improvable in 5 (20%) and 3 (9%), inadequate in 6 (24%) and 3 (9%), respectively. In the two cohorts, four patients (16%) and six patients (18%) developed other autoimmune diseases.
Twenty years after the diagnosis, near half of the patients diagnosed in a mass screening, does not have an optimal adherence to the gluten-free diet and a remarkable proportion of them have developed another autoimmune disease.
调查通过大规模筛查在儿童时期确诊的成年乳糜泻患者在诊断后 20 年对无麸质饮食的依从性。
这是一项观察性历史队列随访研究。它在意大利的里雅斯特母婴健康研究所（IRCCS Burlo Garofolo）进行。招募了两组通过大规模筛查或因症状而在儿童时期确诊的成年乳糜泻患者。通过电话访谈过程中的问卷调查来调查对无麸质饮食的依从性和自身免疫性疾病的发展情况。主要研究结果是通过比阿吉问卷测量两组乳糜泻患者对无麸质饮食的依从性。
我们联系了 25 名（平均年龄 28 岁，19 名女性）通过筛查诊断的患者和 34 名（平均年龄 25 岁，26 名女性）同期因症状诊断的患者。20 年后，在筛查诊断组和症状诊断组中，无麸质饮食依从性最佳的分别有 14 名（56%）和 26 名（81%），可改善的分别有 5 名（20%）和 3 名（9%），不充分的分别有 6 名（24%）和 3 名（9%）。在这两个队列中，分别有 4 名（16%）和 6 名（18%）患者发生了其他自身免疫性疾病。
在诊断后 20 年，近一半通过大规模筛查诊断的患者对无麸质饮食的依从性不理想，而且其中相当一部分患者已经发展出另一种自身免疫性疾病。
