Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Acta Biochim Biophys Sin (Shanghai). 2021 Nov 10;53(11):1428-1439. doi: 10.1093/abbs/gmab122.
Bone marrow mesenchymal stromal cells (BMMSCs) are widely sourced and easily amplified in vitro; thus, they have a great potential in the treatment of hemopathies. Recent findings suggested that BMMSCs express the aryl hydrocarbon receptor (AHR). However, few studies have reported on the regulation of proliferative behaviors and metabolism by AHR in BMMSCs. In the present study, we found that activating AHR reduced the proliferation of BMMSCs and enhanced their mitochondrial function, whereas inhibiting AHR exerted the opposite effects. This study may provide the basis for further unveiling the molecular mechanisms and therapeutic potential of AHR in BMMSCs.
骨髓间充质基质细胞（BMMSCs）来源广泛，体外扩增容易；因此，它们在血液疾病的治疗中有很大的潜力。最近的研究结果表明，BMMSCs 表达芳香烃受体（AHR）。然而，很少有研究报道 AHR 对 BMMSCs 增殖行为和代谢的调节作用。在本研究中，我们发现激活 AHR 可降低 BMMSCs 的增殖并增强其线粒体功能，而抑制 AHR 则产生相反的效果。这项研究可能为进一步揭示 AHR 在 BMMSCs 中的分子机制和治疗潜力提供基础。
