Group of Skeletal, Mineral and Gonadal Endocrinology, Department of Growth and Reproduction, Rigshospitalet, Copenhagen, 2100, Denmark.
Department of Growth and Reproduction and International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, 2100, Denmark.
J Clin Endocrinol Metab. 2022 Jan 1;107(1):98-108. doi: 10.1210/clinem/dgab667.
Vitamin D has been linked with glucose and lipid metabolism. Men with impaired gonadal function have a higher risk of metabolic syndrome and mortality, and vitamin D status may be a reversible modulator.
This work aimed to determine the effect of daily vitamin D and calcium supplementation for 150 days on glucose and lipid homeostasis in infertile men.
A single-center, double-blinded, randomized clinical trial (NCT01304927) was conducted. A total of 307 infertile men were randomly assigned (1:1) to a single dose of 300 000 IU cholecalciferol followed by 1400 IU cholecalciferol + 500 mg of calcium daily (n = 151) or placebo (n = 156) for 150 days. Reported metabolic parameters including fasting plasma glucose, glycated hemoglobin A1c, fasting serum insulin, homeostatic model assessment of insulin resistance (HOMA-IR), fasting plasma cholesterols, and triglycerides were secondary end points. The primary end point semen quality has previously been reported.
Men receiving vitamin D supplementation improved their vitamin D status, whereas vitamin D status was aggravated in the placebo group characterized by higher serum parathyroid hormone. At the end of the trial, men receiving vitamin D supplementation had 13% lower fasting serum insulin concentrations compared with the placebo-treated group (65 vs 74 pmol/L, P = .018) and 19% lower HOMA-IR (2.2 vs 2.7, P = .025). Moreover, men in the vitamin D group had higher high-density lipoprotein (HDL) cholesterol levels (1.38 vs 1.32 mmol/L, P = .008) compared with the placebo group.
High-dose vitamin D supplementation has beneficial effects on glucose homeostasis and HDL cholesterol levels in infertile men.
维生素 D 与葡萄糖和脂质代谢有关。性腺功能受损的男性患代谢综合征和死亡的风险更高，而维生素 D 状况可能是一种可逆转的调节剂。
本研究旨在确定 150 天每日维生素 D 和钙补充对不育男性葡萄糖和脂质稳态的影响。
进行了一项单中心、双盲、随机临床试验（NCT01304927）。307 名不育男性被随机分为（1:1）接受单次 300000 IU 胆钙化醇，随后每天接受 1400 IU 胆钙化醇+500mg 钙（n=151）或安慰剂（n=156）治疗 150 天。报告的代谢参数包括空腹血糖、糖化血红蛋白 A1c、空腹血清胰岛素、稳态模型评估的胰岛素抵抗（HOMA-IR）、空腹血浆胆固醇和甘油三酯，这些都是次要终点。之前已经报道了主要终点精液质量。
接受维生素 D 补充的男性改善了他们的维生素 D 状况，而安慰剂组的维生素 D 状况恶化，表现为血清甲状旁腺激素升高。试验结束时，与安慰剂组相比，接受维生素 D 补充的男性空腹血清胰岛素浓度降低 13%（65 与 74 pmol/L，P=0.018），HOMA-IR 降低 19%（2.2 与 2.7，P=0.025）。此外，与安慰剂组相比，维生素 D 组男性的高密度脂蛋白（HDL）胆固醇水平更高（1.38 与 1.32 mmol/L，P=0.008）。
高剂量维生素 D 补充对不育男性的葡萄糖稳态和 HDL 胆固醇水平有有益影响。
