Gandy Milena, Heriseanu Andreea I, Dudeney Joanne, Bisby Madelyne A, Scott Amelia J, Fisher Alana, Hathway Taylor, Karin Eyal, Titov Nick, Dear Blake F
Department of Psychology, Faculty of Medicine, Health and Human Sciences, Macquarie University, 4 First Walk, NSW 2019, Australia.
Gen Hosp Psychiatry. 2021 Nov-Dec;73:16-23. doi: 10.1016/j.genhosppsych.2021.08.013. Epub 2021 Sep 2.
This study assessed factors associated with disability and life satisfaction in a large cohort of 2246 Australian adults with neurological disorders who completed an online survey of mental health and wellbeing. It was hypothesised that depressive symptoms and perceived cognitive difficulties would be significantly associated with both outcomes, even after controlling for significant demographic/medical covariates (e.g., age, marital-status, employment, multi-morbidity, medication). Differences in profiles of four neurological subgroups (i.e., multiple sclerosis; n = 738, epilepsy; n = 672, Parkinson's disease; n = 263, and Acquired Bran Injury; n = 278) were explored.
Multiple hierarchical linear regressions were run using cross-sectional data.
Depressive symptoms made a significant and large unique contribution to higher levels of disability (β = 0.333, p < .001), and poorer life satisfaction (β = -0.434, p < .001), in the overall sample and across all four neurological subgroups (β = 0.349 to 0.513, p < .001) Greater perceived cognitive difficulties were associated with disability in the overall sample (β = 0.318, p < .001) and across all neurological subgroups (β = 0.231 to 0.354, p < .001), but only life satisfaction in epilepsy (β = -0.107, p = 006).
The findings underscore the importance of managing psychological/neuropsychiatric comorbidities in neurological disorders.
本研究评估了2246名患有神经系统疾病的澳大利亚成年人队列中与残疾和生活满意度相关的因素，这些成年人完成了一项关于心理健康和幸福感的在线调查。研究假设，即使在控制了重要的人口统计学/医学协变量（如年龄、婚姻状况、就业、多种疾病、药物治疗）之后，抑郁症状和感知到的认知困难仍将与这两个结果显著相关。研究还探讨了四个神经亚组（即多发性硬化症；n = 738、癫痫；n = 672、帕金森病；n = 263和获得性脑损伤；n = 278）的特征差异。
使用横断面数据进行多元分层线性回归分析。
在总体样本以及所有四个神经亚组中，抑郁症状对更高水平的残疾（β = 0.333，p <.001）和更低的生活满意度（β = -0.434，p <.001）均有显著且较大的独特贡献（β = 0.349至0.513，p <.001）。在总体样本（β = 0.318，p <.001）以及所有神经亚组（β = 0.231至0.354，p <.001）中，更大的感知认知困难与残疾相关，但仅在癫痫组中与生活满意度相关（β = -0.107，p = 0.006）。
研究结果强调了在神经系统疾病中管理心理/神经精神共病的重要性。
