Department of Chemistry, Faculty of Science, Lorestan University, Khorramabad, Iran.
Department of Chemistry, Malayer University, Malayer, Iran.
Bioorg Chem. 2021 Nov;116:105308. doi: 10.1016/j.bioorg.2021.105308. Epub 2021 Sep 2.
By coupling a quaternary pyridinium compound and curcumin (CM), a new antimicrobial agent called CP was obtained. The poor water-solubility was the most important limiting factor in the use of CM and CP. To address this problem, a hydrophilic hyperbranched polyglycerol (PG) was synthesized and reacted with CM and CP via Schiff base reaction to form two new macromolecules. Due to the presence of polymer, the solubility and stability of CM and CP increased significantly in aqueous media. Since the new macromolecules were including the hydrophilic polymeric and curcumin hydrophobic units, they self-assembled into spherical nanostructures, which were characterized by Field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) images. The synthetic nanostructures exhibited a controlled release of curcumin unit in the acidic environment. In vitro experiments showed that the new macromolecules are potent antibacterial and antioxidant agents.
通过将一种季铵吡啶化合物与姜黄素（CM）偶联，得到了一种名为 CP 的新型抗菌剂。CM 和 CP 的水溶性差是其应用的最重要限制因素。为了解决这个问题，合成了一种亲水性超支化聚甘油（PG），并通过席夫碱反应与 CM 和 CP 反应，形成了两种新的大分子。由于聚合物的存在，CM 和 CP 在水介质中的溶解度和稳定性显著提高。由于新的大分子包括亲水性聚合物和姜黄素疏水性单元，它们在水溶液中自组装成球形纳米结构，这通过场发射扫描电子显微镜（FE-SEM）和透射电子显微镜（TEM）图像进行了表征。合成的纳米结构在酸性环境中表现出姜黄素单元的控制释放。体外实验表明，新的大分子是有效的抗菌和抗氧化剂。
