阳性切缘对口腔鳞状细胞癌生存的影响。
The impact of positive margin on survival in oral cavity squamous cell carcinoma.
机构信息
Department of Otolaryngology, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania, United States.
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States.
出版信息
Oral Oncol. 2021 Nov;122:105499. doi: 10.1016/j.oraloncology.2021.105499. Epub 2021 Sep 9.
BACKGROUND
Positive margins are known to impact survival in oral cavity squamous cell carcinoma (OCSCC). We aimed to determine the impact of positive margins on survival and whether radiation improves survival following positive margins.
METHODS
Data was obtained from the National Cancer Database and included patients with cT1T2N0 OCSCC. Survival outcomes were assessed via log-rank test. Cox-regression analysis was performed to determine if positive margins or radiation, when applicable, correlated with survival after accounting for covariates.
RESULTS
Positive margin patients had worse overall survival compared to negative margin control (HR = 1.76, p < 0.001) and reduced survival by 13%. On multivariate analysis, positive margins correlated with survival (HR = 1.60, p < 0.001). Radiation did not improve survival in positive margin patients (HR = 0.99, p = 0.55).
CONCLUSIONS
Patients with positive margins have an 11-15% worse overall survival. Radiation does not appear to impact survival in patients with a positive margin.
背景
阳性切缘已知会影响口腔鳞状细胞癌（OCSCC）的生存。我们旨在确定阳性切缘对生存的影响，以及放射治疗是否能改善阳性切缘后的生存。
方法
数据来自国家癌症数据库，包括 cT1T2N0 口腔鳞状细胞癌患者。通过对数秩检验评估生存结果。通过 Cox 回归分析，确定阳性切缘或放射治疗（如适用）是否与在考虑协变量后与生存相关。
结果
与阴性切缘对照组相比，阳性切缘患者的总生存率更差（HR=1.76，p<0.001），生存减少了 13%。在多变量分析中，阳性切缘与生存相关（HR=1.60，p<0.001）。放射治疗并未改善阳性切缘患者的生存（HR=0.99，p=0.55）。
结论
阳性切缘患者的总生存率降低了 11-15%。放射治疗似乎不会影响阳性切缘患者的生存。
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