Spence Ryland N, Au Vivienne H, Zhao Yan, Feng Allen L, Juliano Amy F, Goss Deborah, Varvares Mark A
The Warren Alpert Medical School of Brown University Providence Rhode Island USA.
Department of Otolaryngology-Head and Neck Surgery New York-Presbyterian Hospital, Columbia University and Weill Cornell Schools of Medicine New York New York USA.
OTO Open. 2024 Jun 6;8(2):e147. doi: 10.1002/oto2.147. eCollection 2024 Apr-Jun.
To evaluate for correlation between intraoperative ultrasound (IOUS)-measured tumor thickness (TT) (uTT) and histopathological TT (hTT), and to compare IOUS-assisted resection with conventional resection in patients with oral tongue cancers.
Ovid MEDLINE (1946-2023), Embase.com (1947-2023), and Web of Science (All Databases 1900-2023).
Inclusion criteria were the use of IOUS for the management of oral tongue cancer. Studies that did not report quantitative data were excluded. Additionally, studies that were not contributory to meta-analysis, or a narrative analysis of pooled results were excluded. Selection was carried out by 2 reviewers. A total of 2417 studies were initially identified, with 12 ultimately being included in this review, and 7 included in the meta-analysis. Data were extracted by 2 investigators and were pooled using a random-effects model.
Our meta-analysis reveals a pooled correlation coefficient of 0.92 (95% confidence interval: 0.80-0.96) for studies comparing uTT to hTT. Studies comparing IOUS-assisted resection to conventional resection found IOUS-assisted resection yielded wider nearest margins in all studies reporting this outcome.
IOUS reliably measures TT, similarly to that of histopathology measurement. IOUS-assisted resection, which allows the surgeon to view the deep extent of tumor invasion, may increase closest radial margin distance compared to conventional resection. IOUS-assisted resection may represent a more reliable approach to achieving clear margins than conventional resection.
评估术中超声（IOUS）测量的肿瘤厚度（TT）（uTT）与组织病理学TT（hTT）之间的相关性，并比较IOUS辅助切除术与传统切除术在口腔舌癌患者中的效果。
Ovid MEDLINE（1946 - 2023）、Embase.com（1947 - 2023）和Web of Science（所有数据库1900 - 2023）。
纳入标准为使用IOUS治疗口腔舌癌。未报告定量数据的研究被排除。此外，对荟萃分析无贡献或无法对汇总结果进行叙述性分析的研究也被排除。由2名审阅者进行筛选。最初共识别出2417项研究，最终12项被纳入本综述，7项被纳入荟萃分析。数据由2名研究人员提取，并使用随机效应模型进行汇总。
我们的荟萃分析显示，在比较uTT和hTT的研究中，汇总相关系数为0.92（95%置信区间：0.80 - 0.96）。比较IOUS辅助切除术与传统切除术的研究发现，在所有报告该结果的研究中，IOUS辅助切除术产生的最近切缘更宽。
IOUS能够可靠地测量TT，与组织病理学测量相似。IOUS辅助切除术使外科医生能够查看肿瘤浸润的深度，与传统切除术相比，可能会增加最近的径向切缘距离。与传统切除术相比，IOUS辅助切除术可能是一种更可靠的实现切缘阴性的方法。
