Resident, Oral & Maxillofacial Pathology, Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL, USA.
Unit Director, Bone & Soft Tissue Pathology, Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 Jan;133(1):e26-e32. doi: 10.1016/j.oooo.2021.07.004. Epub 2021 Jul 15.
We present a patient with bone abnormalities and a myriad of lesions secondary to his redeveloping renal failure and neurofibromatosis type 1 (NF1). A 21-year-old male renal transplant recipient with NF1 presented with painless masses and large, irregular radiolucent lesions in the maxilla and mandible. After histologic examination, the lesion was diagnosed as a central odontogenic fibroma (COdF) in association with a central giant cell lesion, most consistent with brown tumor of hyperparathyroidism. The bone changes were interpreted to be highly suggestive of renal osteodystrophy. Around 30 cases of hybrid central giant cell granuloma-like lesion in association with central odontogenic fibroma have been reported. This, to our knowledge, is the first reported case of brown tumor in association with COdF. Our case provides further evidence of the giant cell component as the initiating entity in these hybrid lesions.
我们报告了一例因肾功能衰竭和神经纤维瘤病 1 型（NF1）再发而导致骨骼异常和多种病变的患者。一名 21 岁的男性 NF1 肾移植受者出现无痛性肿块和上颌骨和下颌骨的大而不规则的透亮病变。组织学检查后，该病变被诊断为伴有中央巨细胞病变的中心性牙源性纤维瘤（COdF），最符合甲状旁腺功能亢进棕色瘤。骨骼变化强烈提示肾性骨营养不良。已经报道了约 30 例与中央性牙源性纤维瘤相关的混合性中央巨细胞性类肉芽肿样病变。据我们所知，这是首例与 COdF 相关的棕色瘤病例。我们的病例进一步证明了巨细胞成分是这些混合病变的起始实体。
