Department of Oral Biology and Oral Pathology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Department of Oral Biology and Oral Pathology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 Jan;133(1):e20-e25. doi: 10.1016/j.oooo.2021.06.010. Epub 2021 Jun 21.
Ameloblastoma is a locally aggressive, benign epithelial odontogenic neoplasm currently classified to include conventional, unicystic, and extraosseous/peripheral subtypes. Giant cells have been reported in various malignancies but rarely in odontogenic neoplasms. To date, only a single case of unicystic ameloblastoma with stromal giant cells has been reported in the literature. We report two new cases with histologic features compatible with unicystic ameloblastoma with stromal giant cells. CD68 immunohistochemical staining of the giant cells supported a histiocytic origin. Further research is needed to better understand the origin and nature of these giant cells.
成釉细胞瘤是一种局部侵袭性良性上皮性牙源性肿瘤，目前分为普通型、单囊型和骨外型/外周型。巨细胞已在各种恶性肿瘤中报道，但在牙源性肿瘤中很少见。迄今为止，文献中仅报道了一例伴基质巨细胞的单囊型成釉细胞瘤。我们报告了两个具有组织学特征与伴基质巨细胞的单囊型成釉细胞瘤相符的新病例。巨细胞的 CD68 免疫组化染色支持其组织来源为组织细胞。需要进一步的研究来更好地理解这些巨细胞的起源和性质。
