Shen Xueqin, Wang Wei, Niu Xiaoping
Department of Gastroenterology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui Province, People's Republic of China.
Int J Gen Med. 2021 Aug 29;14:5029-5038. doi: 10.2147/IJGM.S329911. eCollection 2021.
Inflammation factors affect the prognosis of hepatocellular carcinoma (HCC). However, it is not clear if the preoperative neutrophil lymphocyte ratio to albumin ratio (NLRAR) and white blood cell to hemoglobin ratio (WHR) affect the prognosis of HCC post curative hepatectomy. We assessed the prognostic values of NLRAR and WHR in patients suffering from HCC who underwent curative resection.
A total of 169 eligible HCC cases were reviewed. The optimal cut-off values for NLRAR and WHR were selected using the X-tile software. The overall survival (OS) rate was assessed following the Kaplan-Meier analysis method. The Log rank test and Cox proportional hazard regression model were also used to analyze the data. The prognostic values of NLRAR and WHR were calculated by analyzing the area under the receiver operating characteristic curve (AUC). The decision curve analysis (DCA) was performed for clinical benefits.
The OS rate recorded for the high NLRAR group was poorer than the OS rate recorded for the low NLRAR group. Similar trends were observed for WHR. The NLRAR and WHR were the independent predictors of OS. The results were based on the multivariate Cox analyses method. Results obtained by analyzing the subgroups revealed that NLRAR and WHR could be used for the prognosis of HCC in tumor stage I-patients. The NLRAR-WHR scoring system (NWS) could be used to classify HCC patients into two cohorts with different prognoses. This scoring system was more efficient than NLRAR or WHR in predicting OS.
The preoperative NLRAR and WHR are effective prognostic indicators for HCC in patients who underwent curative hepatectomy.
炎症因子影响肝细胞癌（HCC）的预后。然而，术前中性粒细胞与淋巴细胞比值与白蛋白比值（NLRAR）和白细胞与血红蛋白比值（WHR）是否影响根治性肝切除术后HCC的预后尚不清楚。我们评估了NLRAR和WHR在接受根治性切除的HCC患者中的预后价值。
共回顾了169例符合条件的HCC病例。使用X-tile软件选择NLRAR和WHR的最佳截断值。采用Kaplan-Meier分析方法评估总生存率（OS）。还使用对数秩检验和Cox比例风险回归模型分析数据。通过分析受试者工作特征曲线（AUC）下的面积计算NLRAR和WHR的预后价值。进行决策曲线分析（DCA）以评估临床获益。
高NLRAR组的OS率低于低NLRAR组。WHR也观察到类似趋势。NLRAR和WHR是OS的独立预测因素。结果基于多变量Cox分析方法。亚组分析结果显示，NLRAR和WHR可用于I期肿瘤患者HCC的预后评估。NLRAR-WHR评分系统（NWS）可用于将HCC患者分为两个预后不同的队列。该评分系统在预测OS方面比NLRAR或WHR更有效。
术前NLRAR和WHR是接受根治性肝切除术的HCC患者有效的预后指标。
