Liu Yang, Zhang Yunyan, Chen Cha, Li Youqiang
The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China.
Department of Stomatology, Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong 510000, P.R. China.
Biomed Rep. 2021 Oct;15(4):85. doi: 10.3892/br.2021.1461. Epub 2021 Aug 13.
Long non-coding RNAs (lncRNAs) are transcripts that are >200 nucleotides, but with no open reading frame. An increasing number of lncRNAs have been identified following the development of second-generation sequencing technologies, and they have since become a research hotspot. Functionally, they play a vital role in tumor progression, including in tumor proliferation, migration, invasion, apoptosis and acquisition of drug resistance. They regulate gene expression primarily through interaction with DNA, RNA and proteins at the epigenetic, transcriptional and post-transcriptional levels. Endogenous hypoxia-inducible factor 1α antisense RNA 2 (lncRNA HIF1A-AS2) is aberrantly expressed and involved the development/progression of various types of tumors, such as bladder cancer, glioblastoma, breast cancer and osteosarcoma. It plays a vital role in the proliferation, apoptosis, migration, invasion and epithelial-mesenchymal transformation of various tumor cells. This review summarizes the current body of knowledge on the biological functions and related molecular mechanisms of lncRNA HIF1A-AS2 in the development/progression of human tumors and other diseases.
长链非编码RNA（lncRNAs）是长度大于200个核苷酸但没有开放阅读框的转录本。随着第二代测序技术的发展，越来越多的lncRNAs被鉴定出来，此后它们成为了一个研究热点。在功能上，它们在肿瘤进展中发挥着至关重要的作用，包括肿瘤增殖、迁移、侵袭、凋亡以及获得耐药性。它们主要通过在表观遗传、转录和转录后水平与DNA、RNA和蛋白质相互作用来调节基因表达。内源性缺氧诱导因子1α反义RNA 2（lncRNA HIF1A-AS2）表达异常，并参与多种类型肿瘤的发生/进展，如膀胱癌、胶质母细胞瘤、乳腺癌和骨肉瘤。它在各种肿瘤细胞的增殖、凋亡、迁移、侵袭和上皮-间质转化中起着至关重要的作用。本综述总结了目前关于lncRNA HIF1A-AS2在人类肿瘤及其他疾病发生/进展中的生物学功能和相关分子机制的知识体系。
