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一名四岁儿童因肺结核导致距骨溶骨性病变且无相邻骨骼受累的罕见病例。

A Rare Case of Tuberculosis as a Cause of Lytic Lesion of Talus Without Adjacent Bone Involvement in a Four-Year-Old Child.

作者信息

Sahoo Samrat S, Tiwari Vivek, Velagada Sandeep

机构信息

Orthopaedics, All India Institute of Medical Science Nagpur, Nagpur, IND.

Orthopaedics, Saheed Laxman Nayak Medical College and Hospital, Koraput, IND.

出版信息

Cureus. 2021 Aug 5;13(8):e16909. doi: 10.7759/cureus.16909. eCollection 2021 Aug.

DOI:10.7759/cureus.16909
PMID:34513482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8418272/
Abstract

Extra-pulmonary tuberculosis still remains an important differential diagnosis for chronic musculoskeletal ailments in developing countries like India and may involve any part of the body without characteristic systemic features. We are presenting a rare case of a four-year-old female child, who came to our tertiary-care hospital with chief complaints of pain in the left foot along with a gradually increasing swelling over the dorsum of the foot for the past five months. There was no history of trauma or constitutional symptoms. The serum inflammatory markers were found raised, and X-ray and magnetic resonance imaging revealed an isolated lytic lesion in the talus bone. Debridement, as well as curettage of the lesion, was done, both as a diagnostic and therapeutic procedure. A caseous cheesy material was evacuated and sent for microbiological and histopathological evaluation, which revealed the presence of acid-fast bacilli and granulomatous lesion confirming the diagnosis of tuberculosis. The patient was started with anti-tubercular chemotherapy, which continued for a total duration of 14 months, along with foot and ankle immobilization in a below-knee cast for three months. After completion of therapy, there was complete resolution of the lytic lesion on x-ray, with full symptom relief, and a full range of movement of the ankle was obtained. In cases with longstanding pain and swelling of the foot, with or without associated systemic symptoms, tuberculosis should be considered as a strong differential diagnosis even in young children, especially in developing countries. Diagnostic and therapeutic curettage along with anti-tubercular chemotherapy can result in a good functional outcome in such patients.

摘要

在印度等发展中国家,肺外结核仍是慢性肌肉骨骼疾病的重要鉴别诊断,可能累及身体任何部位且无典型全身症状。我们报告一例罕见病例,一名4岁女童因左足疼痛及足背肿胀逐渐加重5个月前来我院三级医疗机构就诊。无外伤史或全身症状。血清炎症标志物升高,X线和磁共振成像显示距骨有孤立性溶骨性病变。对病变进行了清创及刮除术,作为诊断和治疗手段。清除了干酪样物质并送去进行微生物学和组织病理学评估,结果显示存在抗酸杆菌和肉芽肿性病变,确诊为结核。患者开始接受抗结核化疗,共持续14个月,同时用膝下石膏固定足和踝关节3个月。治疗结束后,X线显示溶骨性病变完全消退,症状完全缓解,踝关节活动范围恢复正常。对于有足部长期疼痛和肿胀、有无相关全身症状的病例,即使是幼儿,尤其是在发展中国家,也应将结核视为重要的鉴别诊断。诊断性和治疗性刮除术联合抗结核化疗可使此类患者获得良好的功能预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d7/8418272/310ed2c28cba/cureus-0013-00000016909-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d7/8418272/8c5408d252bd/cureus-0013-00000016909-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d7/8418272/942fe00a1a53/cureus-0013-00000016909-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d7/8418272/48d41518761d/cureus-0013-00000016909-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d7/8418272/310ed2c28cba/cureus-0013-00000016909-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d7/8418272/8c5408d252bd/cureus-0013-00000016909-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d7/8418272/942fe00a1a53/cureus-0013-00000016909-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d7/8418272/48d41518761d/cureus-0013-00000016909-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d7/8418272/310ed2c28cba/cureus-0013-00000016909-i04.jpg

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