Abdolmaleki Arash, Asadi Asadollah, Gurushankar Krishnamoorthy, Karimi Shayan Tahereh, Abedi Sarvestani Fatemeh
Department of Engineering Sciences, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran.
Bio Science and Biotechnology Research center (BBRC), Sabalan University of Advanced Technologies (SUAT), Namin, Iran.
Adv Pharm Bull. 2021 May;11(3):450-457. doi: 10.34172/apb.2021.052. Epub 2020 Oct 19.
Cancer is one of the deadly diseases leading to approximately 7.6 million deaths worldwide, with the mortality rate of 13%, and the number of deaths is expected to increase to 13.1 million within the next 10 years. In controlled drug delivery systems (DDS), the drug is transported to the desired location. Thus, the influence of drugs on vital tissues and undesirable side effects can be minimised. Additionally, DDS protects the drug from rapid degradation or clearance and enhances drug concentration in target tissues, and therefore, minimise the required dose of drug. This modern form of therapy is particularly important when there is a discrepancy between the dose and concentration of a drug. Cell-specific targeting can be achieved by attaching drugs to individually designed carriers. Recent developments in nanotechnology have shown that nanoparticles (particles with diameter < 100 nm in at least one dimension) have great potential as drug carriers. Because of their small size, these nanostructures exhibit unique physicochemical and biological properties that make them a favourable material for biomedical applications. Therefore, in this review, we aimed to describe the importance and types of nanomedicines and efficient ways in which new drug delivery systems for the treatment of cancer can be developed.
癌症是导致全球约760万人死亡的致命疾病之一,死亡率为13%,预计在未来10年内死亡人数将增至1310万。在控释给药系统(DDS)中,药物被输送到预期位置。因此,可以将药物对重要组织的影响和不良副作用降至最低。此外,DDS可保护药物不被快速降解或清除,并提高靶组织中的药物浓度,从而将所需药物剂量降至最低。当药物剂量与浓度存在差异时,这种现代治疗形式尤为重要。通过将药物附着在单独设计的载体上可实现细胞特异性靶向。纳米技术的最新进展表明,纳米颗粒(至少在一个维度上直径<100nm的颗粒)作为药物载体具有巨大潜力。由于其尺寸小,这些纳米结构具有独特的物理化学和生物学特性,使其成为生物医学应用的理想材料。因此,在本综述中,我们旨在描述纳米药物的重要性和类型,以及开发用于治疗癌症的新型给药系统的有效方法。