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纳米医学在癌症治疗中的应用面临新的挑战。

New challenges in the use of nanomedicine in cancer therapy.

机构信息

Center of Excellence in Genomic Medicine Research, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan.

出版信息

Bioengineered. 2022 Jan;13(1):759-773. doi: 10.1080/21655979.2021.2012907.

Abstract

Nanomedicines are applied as alternative treatments for anticancer agents. For the treatment of cancer, due to the small size in nanometers (nm), specific site targeting can be achieved with the use of nanomedicines, increasing their bioavailability and conferring fewer toxic side effects. Additionally, the use of minute amounts of drugs can lead to cost savings. In addition, nanotechnology is effectively applied in the preparation of such drugs as they are in nm sizes, considered one of the earliest cutoff values for the production of products utilized in nanotechnology. Early concepts described gold nanoshells as one of the successful therapies for cancer and associated diseases where the benefits of nanomedicine include effective active or passive targeting. Common medicines are degraded at a higher rate, whereas the degradation of macromolecules is time-consuming. All of the discussed properties are responsible for executing the physiological behaviors occurring at the following scale, depending on the geometry. Finally, large nanomaterials based on organic, lipid, inorganic, protein, and synthetic polymers have also been utilized to develop novel cancer cures.

摘要

纳米医药被用作抗癌药物的替代疗法。在癌症治疗中,由于纳米(nm)的尺寸较小,可以使用纳米医药实现特定部位的靶向,从而提高其生物利用度并减少毒性副作用。此外,使用少量药物可以节省成本。此外,纳米技术在这些药物的制备中得到了有效应用,因为它们的尺寸在纳米范围内,被认为是纳米技术产品生产的最早截止值之一。早期的概念将金纳米壳描述为癌症和相关疾病的成功治疗方法之一,其中纳米医药的好处包括有效的主动或被动靶向。普通药物的降解速度更高,而大分子的降解则很耗时。所有讨论的特性都负责执行根据几何形状在以下规模发生的生理行为。最后,还利用基于有机、脂质、无机、蛋白质和合成聚合物的大型纳米材料来开发新的癌症治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e4f/8805951/174fefc274fc/KBIE_A_2012907_UF0001_OC.jpg

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