Chen Jian-Guo, Zhu Jian, Zhang Yong-Hui, Chen Yong-Sheng, Ding Lu-Lu, Chen Hai-Zhen, Shen Ai-Guo, Wang Gao-Ren
Department of Epidemiology, Qidong Liver Cancer Institute, Qidong People's Hospital, Affiliated Qidong Hospital of Nantong University, Qidong, People's Republic of China.
Cancer Institute, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, Nantong, People's Republic of China.
J Hepatocell Carcinoma. 2021 Aug 31;8:1023-1034. doi: 10.2147/JHC.S321346. eCollection 2021.
To explore the long-term trend of liver cancer survival, based on the real-world data (RWD) in the past 45 years from a population-based cancer registry, in Qidong, China.
A number of 32,556 patients with liver cancer were registered during the period of 1972 to 2016. Mixed methods by active and passive follow-up were performed. Life table method was employed for survival analysis by SPSS22 software. Wilcoxon (Gehan) statistics was considered as a significant test. Relative survival was calculated by using SURV software, and its annual percent change (APC) was estimated by the Joinpoint Regression Program.
The overall observed survival (OS) rates of 1-, 5-, 10-, and 20-year rates from the data series were 18.51%, 6.28%, 4.03%, and 2.84%, and their relative survival (RS) rates were 18.88%, 6.95%, 4.96%, and 4.49%, respectively. For 24,338 male cases, the 5-year OS and RS rates were 5.93% and 6.54%, and for 8218 female cases, 7.34% and 8.15%, respectively, with values less than 0.01. Survival rates of liver cancer from three 15-year periods of 1972-1986, 1987-2001, and 2002-2016 have increased significantly, with 5-year OS rates of 2.02%, 4.40%, and 10.76%, 5-year RS rates of 2.18%, 4.83%, and 12.18%; 10-year OS and RS rates of 0.95%, 3.00%, and 7.02%, vs 1.13%, 3.65%, and 8.96%, respectively, showing a very significant upward trend (<0.01). There are significant differences among age groups (): those aged 55-64 demonstrated the best OS and RS rates of 5-year, being 8.44% and 9.09%, respectively.
There are significant gender and age differences in the survival rate of liver cancer in Qidong. RWD indicates the relative lower survival rate of liver cancer in this area, but great improvement has been achieved over the past decades.
基于中国启东市一项人群癌症登记处过去45年的真实世界数据（RWD），探讨肝癌生存率的长期趋势。
1972年至2016年期间登记了32556例肝癌患者。采用主动和被动随访相结合的混合方法。使用SPSS22软件采用生命表法进行生存分析。将Wilcoxon（Gehan）统计量视为显著性检验。使用SURV软件计算相对生存率，并通过Joinpoint回归程序估计其年度变化百分比（APC）。
数据系列中1年、5年、10年和20年的总体观察生存率（OS）分别为18.51%、6.28%、4.03%和2.84%，其相对生存率（RS）分别为18.88%、6.95%、4.96%和4.49%。24338例男性病例的5年OS率和RS率分别为5.93%和6.54%，8218例女性病例分别为7.34%和8.15%，P值均小于0.01。1972 - 1986年、1987 - 2001年和2002 - 2016年这三个15年期间的肝癌生存率显著提高，5年OS率分别为2.02%、4.40%和10.76%，5年RS率分别为2.18%、4.83%和12.18%；10年OS率和RS率分别为0.95%、3.00%和7.02%，与之相比分别为1.13%、3.65%和8.96%，呈非常显著的上升趋势（P<0.01）。各年龄组之间存在显著差异（P<0.01）：55 - 64岁年龄组的5年OS率和RS率最高，分别为8.44%和9.09%。
启东市肝癌生存率存在显著的性别和年龄差异。真实世界数据表明该地区肝癌生存率相对较低，但在过去几十年中已取得了很大改善。
