用合成的LR-RH和一种更有效的LH-RH类似物治疗男性孤立性促性腺激素缺乏症。

Treatment of isolated gonadotropin deficiency in men with synthetic LR-RH and a more potent analogue of LH-RH.

作者信息

Tharandt L, Schulte H, Benker G, Hackenberg K, Reinwein D

出版信息

Neuroendocrinology. 1977;24(3-4):195-207. doi: 10.1159/000122708.

Abstract

Six patients with idiopathic isolated gonadotropin deficiency (IGD) were treated with 100 microgram LH-RH s.c. 3 times daily, leading to subnormal increases of serum gonadotropin (Gn) and testosterone (T) levels, and promoting puberty from stage I to stage II-III of TANNER. S.c. administration of 100 microgram of the more potent and longer-lasting analogue 6-D-Leu-10-Des-Gly-ethylamide-LH-RH induced LH and FSH rises after the very first application in these patients for more than 12 h. However, long-term therapy with the analogue (100 microgram s.c./day) did not improve hypogonadism. Paradoxically, on daily treatment (8 patients) with 6-D-Leu-10-Des-Gly-ethylamide-LH-RH the FSH serum levels fell after 1 week and the LH levels after 8 weeks of treatment.

摘要

6例特发性孤立性促性腺激素缺乏症（IGD）患者接受皮下注射100微克促黄体生成素释放激素（LH-RH）治疗，每日3次，导致血清促性腺激素（Gn）和睾酮（T）水平升高未达正常，且使性发育从坦纳I期进展至II - III期。皮下注射100微克更强效且作用更持久的类似物6 - D - 亮氨酸 - 10 - 去甘氨酸 - 乙酰胺 - LH - RH，在这些患者首次应用后12小时以上就引起了促黄体生成素（LH）和促卵泡生成素（FSH）升高。然而，用该类似物进行长期治疗（100微克皮下注射/天）并未改善性腺功能减退。矛盾的是，对8例患者每日用6 - D - 亮氨酸 - 10 - 去甘氨酸 - 乙酰胺 - LH - RH治疗，治疗1周后血清FSH水平下降，治疗8周后LH水平下降。