Zhou Yan, Li Shenpan, Zhang Jianying, Zhang Jinzhou, Wang Zhou, Pan Liubo, Huang Baiqiang, Huang Ke, Chen Xiao, Zhao Qionghui, Jiang Tianjiu, Liu Jianjun
Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, No. 8 Longyuan Road, Nanshan District, Shenzhen, Guangdong, 518055, People's Republic of China.
Food Inspection & Quarantine Center, Shenzhen Custom, Shenzhen, Guangdong, 518045, People's Republic of China.
Environ Sci Pollut Res Int. 2022 Feb;29(7):10222-10234. doi: 10.1007/s11356-021-16249-4. Epub 2021 Sep 13.
Paralytic shellfish toxins (PSTs) produced by certain marine dinoflagellates accumulate in filter-feeding marine bivalves. We used LC-MS/MS to detect and quantify 13 PSTs in 188 shellfish samples of 14 species collected from Shenzhen city's Buji seafood wholesale market from March 2019 to February 2020. Twenty-six of 188 shellfish samples (13.8%) were PSTs detectable. Within 14 species, 10 out of 34 noble clam Chlamys nobilis samples contain detectable PSTs with the highest detection rate 29.4%. Seven out of 17 samples from Nan'ao island contained detectable PSTs with the highest detection rate 41.2% among 11 origins. Samples containing PSTs were concentrated in spring and winter, with the highest levels in March>December>January. Among PSTs detected, C1 was dominant. Acute dietary exposure assessment for Shenzhen residents were based on mean adult body weight, 99 percentile daily shellfish consumption of Shenzhen food consumption survey 2008 and maximum PSTs concentration for each shellfish species. The outcome for Chlamys nobilis was 2.4~3.7-fold higher than recommended ARfDs. Mean PSTs concentration, P, and mean shellfish consumption were used to assess chronic dietary exposure. The results were lower than recommended ARfDs. In conclusion, residents in Shenzhen are at risk for acute PSTs poisoning, while relatively safe from chronic PSTs exposure.
某些海洋甲藻产生的麻痹性贝类毒素（PSTs）会在滤食性海洋双壳贝类中蓄积。我们利用液相色谱-串联质谱法（LC-MS/MS）对2019年3月至2020年2月从深圳市布吉海鲜批发市场采集的14个物种的188份贝类样本中的13种PSTs进行了检测和定量。188份贝类样本中有26份（13.8%）可检测到PSTs。在14个物种中，34份华贵栉孔扇贝样本中有10份含有可检测到的PSTs，检出率最高，为29.4%。南澳岛的17份样本中有7份含有可检测到的PSTs，在11个产地中检出率最高，为41.2%。含有PSTs的样本集中在春季和冬季，3月>12月>1月时含量最高。在检测到的PSTs中，C1占主导地位。基于深圳居民的平均成年体重、2008年深圳食物消费调查中贝类每日消费量的第99百分位数以及每种贝类物种的PSTs最大浓度，对深圳居民进行了急性膳食暴露评估。华贵栉孔扇贝的评估结果比推荐的急性参考剂量（ARfDs）高2.4至3.7倍。采用PSTs平均浓度、P以及贝类平均消费量来评估慢性膳食暴露。结果低于推荐的ARfDs。总之，深圳居民存在急性PSTs中毒风险，而慢性PSTs暴露风险相对较低。
