衰老肺部中的血管重构的机械生物学。
The Mechanobiology of Vascular Remodeling in the Aging Lung.
机构信息
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.
出版信息
Physiology (Bethesda). 2022 Jan 1;37(1):28-38. doi: 10.1152/physiol.00019.2021. Epub 2021 Sep 13.
Abstract
Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature and explore how interacting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs.
摘要
衰老是伴随着肺功能下降和肺部疾病易感性增加的。越来越多的证据支持内皮功能障碍和血管重构在这些变化中的作用，但潜在机制仍不清楚。在这篇综述中，我们总结了衰老肺部血管的功能、结构和分子变化，并探讨了相互作用的衰老和机械生物学线索如何驱动肺部的进行性血管重构。
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