Department of Mathematics and Computer Science, The Open University of Israel, POB 808, Raanana 4353701, Israel.
Cutaneous Microbiology Laboratory, The Skin Research Institute, The Dead Sea and Arava Science Center, Masada 8693500, Israel.
Acta Derm Venereol. 2021 Nov 24;101(11):adv00603. doi: 10.2340/00015555-3929.
The bacterial community that colonizes the human face imparts physiochemical and physiological effects on the facial skin. These skin-microbe interactions impact dermatological, cosmetic and skincare applications due to the centrality of the human face in daily interactions. However, fine-scale characterization of the human face skin microbiome is lacking. Using 16S rRNA sequencing and 3D cartography, this study plotted and characterized the facial skin microbiome in high- definition, based on 1,649 samples from 12 individuals. Analysis yielded a number of novel insights, including that of the relative uniformity of skin microbiome composition within skin sites, site localization of certain microbes, and the interpersonal variability of the skin microbiome. The results show that high-resolution topographical mapping of the skin microbiome is a powerful tool for studying the human skin microbiome. Despite a decade of skin microbiome research, there is still much to be discovered.
定植在人脸上的细菌群落对面部皮肤具有理化和生理学影响。由于人脸在日常互动中的核心地位，这些皮肤-微生物相互作用影响了皮肤科、化妆品和皮肤护理的应用。然而，人们对面部皮肤微生物组的精细特征还知之甚少。本研究使用 16S rRNA 测序和 3D 绘图技术，基于 12 名个体的 1649 个样本，以高清晰度绘制和描述了面部皮肤微生物组。分析产生了一些新的见解，包括皮肤微生物组组成在皮肤部位内的相对均匀性、某些微生物的部位定位以及皮肤微生物组的个体间可变性。结果表明，皮肤微生物组的高分辨率地形测绘是研究人类皮肤微生物组的有力工具。尽管已经进行了十年的皮肤微生物组研究，但仍有许多未知之处。
