Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
Science. 2020 May 29;368(6494):973-980. doi: 10.1126/science.aay9189.
Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients' smoking status, and the response to immunotherapy.
细菌最早在 100 多年前就被发现在人类肿瘤中，但由于其生物量低，肿瘤微生物组的特征一直具有挑战性。我们对肿瘤微生物组进行了全面分析，研究了包括乳腺癌、肺癌、卵巢癌、胰腺癌、黑色素瘤、骨癌和脑癌在内的七种癌症类型的 1526 个肿瘤及其相邻正常组织。我们发现，每种肿瘤类型都有独特的微生物组组成，而乳腺癌具有特别丰富和多样的微生物组。肿瘤内细菌主要是细胞内的，存在于癌症和免疫细胞中。我们还注意到肿瘤内细菌或其预测功能与肿瘤类型和亚型、患者吸烟状况以及对免疫疗法的反应之间存在相关性。
