College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, Guangdong, People's Republic of China.
Guangdong Provincial Key Laboratory of Prevention and Control for Severe Clinical Animal Diseases, Guangzhou, 510642, Guangdong, People's Republic of China.
Arch Virol. 2021 Nov;166(11):3221-3224. doi: 10.1007/s00705-021-05228-2. Epub 2021 Sep 13.
Equine hepacivirus (EqHV) is a newly discovered hepatitis C virus-like virus that can infect equines. EqHV strains circulating worldwide have been classified into subtypes 1-3. In previous studies, we detected the presence of EqHV strains of subtype 1 and 3 in China. To determine whether EqHV strains of subtype 2 are prevalent in China, serum samples were collected from 133 racehorses in Guangdong province in 2021 and were tested for EqHV RNA by RT-PCR, and the positive rate was 9% (12/133). Sequencing of the NS3 gene revealed that one field strain (GD2021) had a high degree of genetic similarity to EqHV strains of subtype 2. Subsequent genome sequencing and analysis demonstrated that strain GD2021 belongs to subtype 2. The present study enriches our knowledge about the genetic diversity of EqHV in China.
马乙型肝炎病毒（EqHV）是一种新发现的丙型肝炎病毒样病毒，可感染马属动物。目前已发现的全球流行的 EqHV 毒株可分为 1-3 个亚型。在之前的研究中，我们在中国检测到了 1 型和 3 型 EqHV 毒株。为了确定 2 型 EqHV 毒株在中国是否流行，我们于 2021 年从广东省的 133 匹赛马中采集了血清样本，通过 RT-PCR 检测 EqHV RNA，阳性率为 9%（12/133）。对 NS3 基因进行测序发现，一株田间分离株（GD2021）与 2 型 EqHV 株具有高度的遗传相似性。随后的全基因组测序和分析表明，GD2021 株属于 2 型。本研究丰富了我们对中国 EqHV 遗传多样性的认识。
