Centre for Mental Health, Faculty of Health, Arts & Design, Swinburne University of Technology, VIC, 3122, Australia.
Centre for Mental Health, Faculty of Health, Arts & Design, Swinburne University of Technology, VIC, 3122, Australia.
Neurosci Biobehav Rev. 2021 Dec;131:663-687. doi: 10.1016/j.neubiorev.2021.09.006. Epub 2021 Sep 10.
It has been documented that individuals who hear auditory verbal hallucinations (AVH) exhibit diminished capabilities in processing external speech. While functional neuroimaging studies have attempted to characterise the cortical regions and networks facilitating these deficits in a bid to understand AVH, considerable methodological heterogeneity has prevented a consensus being reached. The current systematic review investigated the neurobiological underpinnings of external speech processing deficits in voice-hearers in 38 studies published between January 1990 to June 2020. AVH-specific deviations in the activity and lateralisation of the temporal auditory regions were apparent when processing speech sounds, words and sentences. During active or affective listening tasks, functional connectivity changes arose within the language, limbic and default mode networks. However, poor study quality and lack of replicable results plague the field. A detailed list of recommendations has been provided to improve the quality of future research on this topic.
有文献记载，听觉言语幻觉（AVH）患者在处理外部言语时的能力会下降。虽然功能神经影像学研究试图描述皮质区域和网络，以了解这些缺陷，从而理解 AVH，但相当大的方法学异质性阻碍了达成共识。本系统综述调查了 38 项研究中听觉言语处理缺陷的神经生物学基础，这些研究发表于 1990 年 1 月至 2020 年 6 月之间。在处理语音、单词和句子时，听觉区域的活动和侧化出现了与 AVH 特异性相关的偏差。在主动或情感聆听任务中，语言、边缘和默认模式网络内出现了功能连接变化。然而，该领域存在研究质量差和缺乏可复制结果的问题。为了提高这一主题未来研究的质量，我们提供了一份详细的建议清单。
