Cleveland Clinic Center for Neurological Restoration, Cleveland, OH, USA.
Rhode Island Hospital, Department of Pathology, Providence, RI, USA.
J Neuroimmunol. 2021 Nov 15;360:577716. doi: 10.1016/j.jneuroim.2021.577716. Epub 2021 Sep 7.
We report the appearance of clinical symptoms and signs of N-methyl-d-Aspartate (NMDA) receptor encephalitis in a patient presenting just days after contraction of influenza B. The offending mature ovarian teratoma was identified and removed on the 10th day after the appearance of symptoms, with subsequent nearly complete resolution of symptoms over the subsequent 6 months. We provide a focused literature review of the clinical and pathophysiologic literature of anti-NMDA receptor encephalitis pertaining to influenza B virus and the pediatric population. Taken together, this study contributes to the pathophysiological understanding of anti-NMDA receptor encephalitis and aids clinicians in its early recognition and management.
我们报告了一例在感染乙型流感后仅数天出现 N-甲基-D-天冬氨酸（NMDA）受体脑炎临床症状和体征的患者。在出现症状后的第 10 天，发现并切除了致病的成熟卵巢畸胎瘤，随后在接下来的 6 个月内，症状几乎完全缓解。我们对与乙型流感病毒和儿科人群相关的抗 NMDA 受体脑炎的临床和病理生理学文献进行了重点综述。综上所述，本研究有助于深入了解抗 NMDA 受体脑炎的病理生理学，并有助于临床医生早期识别和治疗。
