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新冠病毒感染后出现的多系统炎症综合征的纵向广泛性横贯性脊髓炎:儿科病例报告。

Longitudinally extensive transverse myelitis as a sign of multisystem inflammatory syndrome following COVID-19 infection: A pediatric case report.

机构信息

Department of Pediatric Infectious, Isfahan University of Medical Sciences, Isfahan, Iran.

Department of Pediatric Intensive Care, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

J Neuroimmunol. 2021 Nov 15;360:577704. doi: 10.1016/j.jneuroim.2021.577704. Epub 2021 Aug 28.

Abstract

COVID-19 infection can cause inflammatory reactions that could involve several organs. In the pediatric population, Multi-System Inflammatory Syndrome in Children (MIS-C) has been reported as one of the consequences of COVID-19. We report a unique pediatric COVID-19 patient with MIS-C, associated with paralysis of the extremities. MRI showed abnormal signal in the cervical spinal cord compatible with transverse myelitis. Methylprednisolone and IVIG were administered, without significant symptom improvement. As a next step, Infliximab was tried for her, and she responded remarkably well to this treatment. Infliximab may be considered as a treatment option in COVID-19 patients with transverse myelitis.

摘要

COVID-19 感染可引起炎症反应,涉及多个器官。在儿科人群中,儿童多系统炎症综合征(MIS-C)已被报道为 COVID-19 的后果之一。我们报告了一例独特的儿科 COVID-19 合并 MIS-C 伴四肢瘫痪的患者。MRI 显示颈髓异常信号,符合横贯性脊髓炎。给予甲基强的松龙和 IVIG 治疗,但症状无明显改善。下一步,给予她英夫利昔单抗治疗,效果显著。英夫利昔单抗可考虑作为 COVID-19 合并横贯性脊髓炎患者的治疗选择。

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