Department of Pediatric Infectious, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pediatric Intensive Care, Isfahan University of Medical Sciences, Isfahan, Iran.
J Neuroimmunol. 2021 Nov 15;360:577704. doi: 10.1016/j.jneuroim.2021.577704. Epub 2021 Aug 28.
COVID-19 infection can cause inflammatory reactions that could involve several organs. In the pediatric population, Multi-System Inflammatory Syndrome in Children (MIS-C) has been reported as one of the consequences of COVID-19. We report a unique pediatric COVID-19 patient with MIS-C, associated with paralysis of the extremities. MRI showed abnormal signal in the cervical spinal cord compatible with transverse myelitis. Methylprednisolone and IVIG were administered, without significant symptom improvement. As a next step, Infliximab was tried for her, and she responded remarkably well to this treatment. Infliximab may be considered as a treatment option in COVID-19 patients with transverse myelitis.
COVID-19 感染可引起炎症反应，涉及多个器官。在儿科人群中，儿童多系统炎症综合征（MIS-C）已被报道为 COVID-19 的后果之一。我们报告了一例独特的儿科 COVID-19 合并 MIS-C 伴四肢瘫痪的患者。MRI 显示颈髓异常信号，符合横贯性脊髓炎。给予甲基强的松龙和 IVIG 治疗，但症状无明显改善。下一步，给予她英夫利昔单抗治疗，效果显著。英夫利昔单抗可考虑作为 COVID-19 合并横贯性脊髓炎患者的治疗选择。
