接种新冠疫苗后发生的横贯性脊髓炎一例。
A case of longitudinally extensive transverse myelitis following vaccination against Covid-19.
机构信息
Klinikum Ernst von Bergmann, Department of Neurology, Charlottenstrasse 72, 14467 Potsdam, Germany.
Klinikum Ernst von Bergmann, Department of Neurology, Charlottenstrasse 72, 14467 Potsdam, Germany; Department of Neurology, Medical Faculty, University Düsseldorf, Düsseldorf, Germany.
出版信息
J Neuroimmunol. 2021 Sep 15;358:577606. doi: 10.1016/j.jneuroim.2021.577606. Epub 2021 Jun 24.
BACKGROUND
Longitudinally extensive transverse myelitis (LETM) is a rare subtype of transverse myelitis (TM) that potentially results in relevant disability. Apart from association to neuromyelitis optica and other chronic demyelinating diseases of the central nervous system, many other aetiologies are known. Particularly systemic infections and vaccination are considered potential triggers for immune mediated inflammation of the spinal cord. In the course of the current Covid-19 pandemic several cases of TM following Covid-19 infection have been described. Here we present a case of LETM following vaccination against Covid-19 with AZD1222, AstraZeneca. An extensive diagnostic work up was performed to rule out alternative causes, including prior and current Covid-19 infection.
CONCLUSION
To our knowledge this is first case of LETM possibly related to Covid-19 vaccination that is published after marketing authorisation of various vaccine candidates.
背景
长节段横贯性脊髓炎（LETM）是一种罕见的横贯性脊髓炎（TM）亚型，可能导致相关残疾。除了与视神经脊髓炎和其他中枢神经系统慢性脱髓鞘疾病有关外，还有许多其他病因。特别是全身感染和疫苗接种被认为是脊髓免疫介导炎症的潜在触发因素。在当前的 COVID-19 大流行期间，已经描述了几例 COVID-19 感染后发生的 TM 病例。在这里，我们报告了一例接种阿斯利康 AZD1222 疫苗后发生的 LETM 病例。进行了广泛的诊断性检查以排除其他病因，包括既往和当前的 COVID-19 感染。
结论
据我们所知，这是在各种疫苗获得许可后首次报道的与 COVID-19 疫苗接种相关的 LETM 病例。
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