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肝硬化合并慢性牙周炎患者的危险因素及营养状况分析

[Risk factors and nutritional status analysis in patients with liver cirrhosis and concomitant chronic periodontitis].

作者信息

Sun X H, Liang J, Wang Y L, Han T, Xu S S

机构信息

Department of Stomatology, Tianjin Third Central Hospital, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Tianjin 300170, China.

Department of Gastroenterology and Hepatology, Tianjin Third Central Hospital, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Tianjin 300170, China.

出版信息

Zhonghua Gan Zang Bing Za Zhi. 2021 Aug 20;29(8):748-753. doi: 10.3760/cma.j.cn501113-20191015-00375.

Abstract

To study and explore the prevalence, characteristics, preliminary risk factors, as well as their relationship with nutritional scores in liver cirrhotic patient with chronic periodontitis. 163 patients with liver cirrhosis who were hospitalized in the Hepatology Division, Department of Internal Medicine at Tianjin Third Central Hospital from June to September 2018 were enrolled as the case group, while the control group consisted 140 healthy individuals enrolled during the same period. Periodontal examination, biochemical examination and oral hygiene habits were investigated. The prevalence of periodontitis in the two groups was compared, and the risk factors of severe periodontitis were conducted by multivariate regression analysis. The prevalence of chronic periodontitis was significantly higher in patients with liver cirrhosis than healthy control population, and the differences were statistically significant ( < 0.05). The prevalence of severe periodontitis and full edentulous jaws was significantly higher in patients with liver cirrhosis than healthy control group, and the differences were statistically significant ( < 0.05 and < 0.001). Compared with the healthy control group, the depth of periodontal pocket and the degree of attachment loss were significantly increased in the liver cirrhosis group ( < 0.001). Multivariate regression analysis showed that liver cirrhosis was the independent risk factors for both groups of patients with severe periodontitis (χ (2) = 11.046, < 0.001). Univariate and multivariate regression analysis showed that toothbrushing frequency, nutritional risk score, prealbumin level and Child-Pugh grade were independent risk factors for occurrence of severe periodontitis in liver cirrhotic patient (χ (2) = 5.252, = 0.022; χ (2) = 24.162, < 0.001; χ (2) = 4.159, = 0.041; χ (2) = 9.249, = 0.002). The prevalence of periodontitis is significantly higher in patients with liver cirrhosis than healthy individuals, and liver cirrhosis is an independent risk factor for the occurrence of severe periodontitis. Toothbrushing frequency, nutritional risk score, prealbumin level and Child-Pugh grade are risk factors for severe periodontitis in patients with liver cirrhosis.

摘要

研究并探讨慢性牙周炎肝硬化患者的患病率、特征、初步危险因素及其与营养评分的关系。选取2018年6月至9月在天津第三中心医院内科肝病科住院的163例肝硬化患者作为病例组,同期选取140例健康个体作为对照组。对两组进行牙周检查、生化检查及口腔卫生习惯调查。比较两组牙周炎患病率,并通过多因素回归分析重度牙周炎的危险因素。肝硬化患者慢性牙周炎患病率显著高于健康对照人群,差异有统计学意义(<0.05)。肝硬化患者重度牙周炎和全口无牙患病率显著高于健康对照组,差异有统计学意义(<0.05和<0.001)。与健康对照组相比,肝硬化组牙周袋深度和附着丧失程度显著增加(<0.001)。多因素回归分析显示,肝硬化是两组重度牙周炎患者的独立危险因素(χ(2)=11.046,<0.001)。单因素和多因素回归分析显示,刷牙频率、营养风险评分、前白蛋白水平和Child-Pugh分级是肝硬化患者发生重度牙周炎的独立危险因素(χ(2)=5.252,=0.022;χ(2)=24.162,<0.001;χ(2)=4.159,=0.041;χ(2)=9.249,=0.002)。肝硬化患者牙周炎患病率显著高于健康个体,肝硬化是重度牙周炎发生的独立危险因素。刷牙频率、营养风险评分、前白蛋白水平和Child-Pugh分级是肝硬化患者重度牙周炎的危险因素。

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