School of Engineering, Macquarie University, Sydney, NSW, 2109, Australia.
School of Engineering, Macquarie University, Sydney, NSW, 2109, Australia; Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 14115-175, Iran.
Talanta. 2021 Dec 1;235:122815. doi: 10.1016/j.talanta.2021.122815. Epub 2021 Aug 19.
Nano structured ion-selective membranes (ISMs) are very attractive materials for a wide range of sensing and ion separation applications. The present review focuses on the design principles of various ISMs; nanostructured and ionophore/ion acceptor doped ISMs, and their use in biomedical engineering. Applications of ISMs in the biomedical field have been well-known for more than half a century in potentiometric analysis of biological fluids and pharmaceutical products. However, the emergence of nanotechnology and sophisticated sensing methods assisted in miniaturising ion-selective electrodes to needle-like sensors that can be designed in the form of implantable or wearable devices (smartwatch, tattoo, sweatband, fabric patch) for health monitoring. This article provides a critical review of recent advances in miniaturization, sensing and construction of new devices over last decade (2011-2021). The designing of tunable ISM with biomimetic artificial ion channels offered intensive opportunities and innovative clinical analysis applications, including precise biosensing, controlled drug delivery and early disease diagnosis. This paper will also address the future perspective on potential applications and challenges in the widespread use of ISM for clinical use. Finally, this review details some recommendations and future directions to improve the accuracy and robustness of ISMs for biomedical applications.
纳米结构离子选择性膜（ISM）是一种非常有吸引力的材料，可用于广泛的传感和离子分离应用。本综述重点介绍了各种 ISM 的设计原则；纳米结构和离子载体/离子受体掺杂的 ISM，以及它们在生物医学工程中的应用。ISM 在生物医学领域的应用已有半个多世纪的历史，可用于生物体液和药物产品的电位分析。然而，纳米技术和复杂的传感方法的出现，有助于将离子选择性电极微型化为针状传感器，这些传感器可以设计成可植入或可穿戴设备（智能手表、纹身、汗带、织物贴片）的形式，用于健康监测。本文对过去十年（2011-2021 年）在微型化、传感和新型器件构建方面的最新进展进行了批判性回顾。具有仿生人工离子通道的可调谐 ISM 的设计提供了广泛的机会和创新的临床分析应用，包括精确的生物传感、药物控制释放和早期疾病诊断。本文还将探讨 ISM 在临床应用中广泛使用的未来前景、潜在应用和挑战。最后，本文详细介绍了一些建议和未来方向，以提高 ISM 用于生物医学应用的准确性和稳健性。
