Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, India.
Infect Disord Drug Targets. 2022;22(2):e130921196420. doi: 10.2174/1871526521666210913110834.
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb), infects the lungs' alveolar surfaces through aerosol droplets. At this stage, the disease progression may have many consequences, determined primarily by the reactions of the human immune system. However, one approach will be to more actively integrate the immune system, especially the pattern recognition receptor (PRR) systems of the host, which notices pathogen-associated molecular patterns (PAMPs) of Mtb. Several types of PRRs are involved in the detection of Mtb, including Toll-like receptors (TLRs), C-type lectin receptors (CLRs), Dendritic cell (DC) -specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), Mannose receptor (MR), and NOD-like receptors (NLRs) related to inflammasome activation. In this study, we focus on reviewing the Mtb pathophysiology and interaction of host PPRs with Mtb as well as adverse drug effects of anti-tuberculosis drugs (ATDs) and systematic TB treatment via Ayurvedic medicine.
结核病（TB）是一种由结核分枝杆菌（Mtb）引起的传染病，通过气溶胶飞沫感染肺部的肺泡表面。在这个阶段，疾病的进展可能会有许多后果，主要取决于人体免疫系统的反应。然而，一种方法将是更积极地整合免疫系统，特别是宿主的模式识别受体（PRR）系统，它可以识别结核分枝杆菌的病原体相关分子模式（PAMPs）。有几种类型的 PRR 参与了结核分枝杆菌的检测，包括 Toll 样受体（TLRs）、C 型凝集素受体（CLRs）、树突状细胞（DC）特异性细胞间黏附分子-3 抓取非整合素（DC-SIGN）、甘露糖受体（MR）和与炎症小体激活相关的 NOD 样受体（NLRs）。在本研究中，我们重点回顾了结核分枝杆菌的病理生理学以及宿主 PRR 与结核分枝杆菌的相互作用，以及抗结核药物（ATD）的不良反应和通过阿育吠陀医学进行系统性结核病治疗。
